This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $243,840 to the University of Pittsburgh to develop innovative approaches for understanding and restoring the normal function of proteins affected by mutations. The key objectives are to reliably distinguish between neutral and deleterious protein mutations and learn how to repair these problems by introducing compensating...
The federal Project Grant award, valued at $697,510.00 and funded by the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program, aims to improve, validate, and interpret amino acid substitution models for protein evolution. The research will enhance understanding of how substitutions of amino acids in proteins impact their form and function, which is critical for reconstructing the evolutionary history of proteins and advancing phylogenetic inference. The project, with a...
This $786,132 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund the continued development and expansion of several computational tools and applications for the biomedical research community. The key products and services to be delivered include: Further enhancing the functionality of the CHARMM-GUI web-based platform to support more force fields, QM/MM interface for enzymatic...
This $752,456 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and application of innovative computational technologies for the design of small-molecule ligands. The key products and services to be delivered over the 5-year project period include: Creating a large database of predicted protein-ligand complexes to improve the accuracy of structure-based machine learning...
This $584,420 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports spatiotemporal mapping and engineering research on the "dark proteome" - intrinsically disordered proteins and their functions. The award, which runs from April 1, 2025 to January 31, 2030, enables researchers at the Albert Einstein College of Medicine to investigate the role of protein disorder in nuclear...
This Project Grant award of $387,500 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research at The Johns Hopkins University to develop computational methods for improving human gene annotation. The funded project aims to address the exponential growth of RNA sequencing data by developing efficient algorithms to process and summarize large transcriptomic datasets. The research efforts will...
This federal Project Grant award of $852,726, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research that aims to elucidate the mechanisms regulating sub-cellular organization and the significance of this organization to organelle and cell function. The award will leverage advanced quantitative microscopy methods developed by the research team to visualize the spatial organization of cells...
This federal Project Grant award of $360,247.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) funds research to explore the diverse mechanisms of Type III CRISPR-Cas signaling in bacteria and archaea. The research aims to elucidate the function and regulation of CRISPR-associated signaling effectors, focusing on nucleases and membrane proteins, using biochemistry, structural biology, and cell biology approaches....
This $360,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate biological mechanisms for proton transfer. The goal is to design photoacid-binding proteins that can spectroscopically study proton dynamics in biological systems. The research will leverage computational protein design tools to position photoacid cofactors within designer protein scaffolds to...
This Project Grant award, with Federal Grant Award ID R01GM155100, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $337,949 award, effective September 1, 2024, supports research by The University of Texas Southwestern Medical Center to define the modular architecture of protein intrinsically disordered regions (IDRs) and develop a predictive understanding of their biological function. The...