Project Grant R01EY037745
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program provides $498,248 to the University of Connecticut Health Center (UCHC) to investigate the molecular mechanisms underlying corneal and retinal injury caused by exposure to chemical threat agents like nitrogen mustard. The key objectives are to: 1) Examine the role of the p53-PAD axis in driving corneal hypercitrullination, a pathological response, after nitrogen...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $1,467,198.00 to the University of Connecticut Health Center (UCHC) to investigate the cellular and molecular mechanisms of corneal and sensory nerve damage caused by exposure to chemical warfare agents. The key products and services to be delivered under this 3-year award, which runs from September 15, 2025 to August...
- This Project Grant award by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $583,250 to The Schepens Eye Research Institute, Inc. to identify the mechanisms underlying ocular toxicity caused by nitrogen mustard exposure and evaluate specialized lipid mediators as potential medical countermeasures. The key objectives are to: 1) Determine how nitrogen mustard alters the function of conjunctival goblet cells and if...
- This is a Project Grant award from the National Eye Institute (NEI), part of the National Institutes of Health (NIH), under the Vision Research program (CFDA 93.867). The $451,000 award supports research by the University of Texas Southwestern Medical Center to investigate the role of the FIC enzyme in regulating the unfolded protein response (UPR) in the mammalian retina. Specifically, the project aims to determine if FIC-mediated modification of the BIP protein can modulate UPR activation,...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) will provide $937,468 to Northwestern University to understand the pathological mechanisms of sulfur mustard gas keratopathy (MGK) in the cornea. The research aims to explore how corneal mustard exposure induces autophagy, a cellular process that can play detrimental roles, via liberating the protein Beclin1 from the Beclin1-Bcl2 complex. The project will conduct in vitro and in...
- This federal Project Grant award, in the amount of $429,000.00, was provided by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant supports research to characterize the biochemical and biological properties of amyloid-beta (Aβ) aggregates found in the eyes of Alzheimer's disease (AD) patients, and to evaluate the potential for these eye-derived Aβ aggregates to induce Aβ pathology in mouse models of AD. The research aims to understand if...
- This Cooperative Agreement award from the National Eye Institute (CFDA 93.867 - Vision Research) aims to develop a novel fenofibrate-loaded microemulsion (FENO-ME) eyedrop as a non-steroid treatment for nitrogen mustard (NM)-induced corneal injury. The $22,677 award to Virginia Commonwealth University (VCU) spans from Sep 2025 to May 2030. The project seeks to: 1) Validate PPARα signaling as a drug target for NM-induced corneal injury and optimize the FENO-ME eyedrop formulation; 2)...
- This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...
- This $440,806 Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) will fund research to define the role of the molecular chaperone protein P58IPK in retinal neurons during the pathogenesis of diabetic retinopathy. The research aims to investigate new molecular pathways by which P58IPK regulates protein and lipid homeostasis through the integrated stress response and lipid glycosylation processes, and evaluate the neuroprotective effects of targeting P58IPK and its...
- This Project Grant award of $423,767 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at the University of California, Davis focused on understanding the role of myeloid cells in glaucoma-related axonal degeneration. The project aims to determine whether NAD+-based interventions can protect retinal ganglion cell axons in a glaucoma-relevant model of axon injury, and to characterize the associated immune response. The research will leverage novel axon injury...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $1,434,104 to the University of Texas Medical Branch at Galveston (UTMB) to investigate the role of the protein SIRT6 in mitigating corneal and retinal injury caused by exposure to the highly toxic chemical acrolein. The 3-year project aims to characterize the pathological changes in the cornea and retina following acrolein exposure using a newly developed mouse model, and to test the hypothesis that SIRT6 plays a critical role in reducing the damage. The research will employ integrated approaches including comprehensive histological analysis and novel imaging-based techniques to better understand the mechanisms underlying acrolein-induced ocular injury and develop potential targeted therapies. This award supports UTMB's expertise in areas such as infectious disease research, medical countermeasure development, and translational scientific studies to address complex medical challenges.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 9/10/25 |