Project Grant R01ES038499
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded Icahn School of Medicine at Mount Sinai a $498,000 Project Grant (CFDA 93.113 – Environmental Health program) effective August 25, 2025, through July 31, 2028, to investigate the neurobiological mechanisms linking prenatal fine particulate air pollution (PM2.5) exposure to neurodevelopmental outcomes in children. The research leverages existing behavioral and multi-modal magnetic resonance imaging...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded Icahn School of Medicine at Mount Sinai a Project Grant valued at $819,506 under the Environmental Health program (CFDA 93.113), effective June 1, 2026, through March 31, 2031. This award supports research to assess pathway-specific stroke risks by examining associations between fine particulate matter (PM2.5) exposure and hemorrhagic and ischemic stroke subtypes. The project delivers...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded $126,970 to Icahn School of Medicine at Mount Sinai on September 10, 2025, under the Environmental Health program (CFDA 93.113) for a research project examining endocrine-disrupting chemical (EDC) mixtures in relation to metabolic syndrome and metabolomic mechanisms in a prospective cohort of Hispanic women. The project, extending through August 31, 2027, will leverage approximately 400...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded $761,550 to Icahn School of Medicine at Mount Sinai on July 25, 2025, under the Environmental Health program (CFDA 93.113) to develop and extend the PFAS Exposure Burden Calculator, a standardized tool for measuring cumulative per- and polyfluoroalkyl substances (PFAS) exposure across populations. Per- and polyfluoroalkyl substances are a class of over 4,000 persistent chemicals associated with...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a $119,524 Project Grant to Harvard T.H. Chan School of Public Health, effective July 1, 2026 through June 30, 2028, under the Environmental Health program (CFDA 93.113). This K99/R00 career development award funds research investigating the biological and psychosocial pathways linking early life lead exposure to later-life cognitive decline. The project leverages the St. Louis Baby...
- Federal Project Grant Award Summary Boston University Medical Campus received a $147,486 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded November 1, 2025, with completion targeted for August 31, 2028. This research project will investigate the neurodevelopmental impacts of early-life exposure to ferroalloy metal mixtures—including manganese, lead, chromium, and copper—on adolescent cognitive...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded the University of Pennsylvania a $124,728 Project Grant on September 8, 2025, under the Environmental Health program (CFDA 93.113) to conduct research on gestational and childhood exposure to endocrine-disrupting chemicals (EDCs) and their effects on adolescent neurobehavior. The research will deliver scientific investigation into the mechanisms by which EDCs—including polybrominated...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded a $1.42 million Project Grant to the Icahn School of Medicine at Mount Sinai on September 17, 2025, for research investigating the urban-social exposome on maternal depression through June 30, 2030. This research will examine how environmental stressors and urban built environments contribute to maternal depression—a condition affecting approximately one in six new mothers worldwide—by...
- Federal Project Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) Environmental Health program (CFDA 93.113) awarded $249,000 to the University of North Carolina at Chapel Hill on August 13, 2025, for a research project extending through July 31, 2028. This Project Grant supports longitudinal research characterizing the early life chemical exposome and its impact on structural and functional brain development in children from birth through age five. The research...
- Federal Project Grant Award Summary Emory University, through its Office of Sponsored Programs, received a $148,614 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective February 16, 2026, through November 4, 2027. The grant funds research investigating the joint effects of prenatal pesticide exposure and psychosocial factors on epigenetic age trajectories and child psychopathology in a South...
The National Institute of Environmental Health Sciences (NIEHS) awarded Icahn School of Medicine at Mount Sinai a $815,546 Project Grant (CFDA 93.113 – Environmental Health) effective June 22, 2026, with completion targeted for April 30, 2031. This research project investigates the impact of early-life chemical mixture exposures on executive function and brain development across adolescence. The study leverages a novel biomarker approach using naturally shed deciduous teeth to obtain precise, time-resolved measures of in utero and early childhood exposures to metals and organic pollutants. By combining this innovative exposure assessment tool with longitudinal neuroimaging and neuropsychological data from the Adolescent Brain Cognitive Development (ABCD) study (approximately 10,000 participants), the research identifies critical developmental windows during which chemical exposures alter trajectories of executive function domains including attention, working memory, and cognitive flexibility. The project delivers research products through three coordinated aims: identification of developmental windows during which chemical mixture exposures impact executive function; determination of associations between exposures and altered development of executive function-related brain regions including the prefrontal cortex, anterior cingulate, hippocampus, and basal ganglia; and assessment of whether brain-based phenotypic changes mediate the relationship between early-life exposures and functional outcomes. This five-year investigation addresses critical gaps in environmental neurotoxicity research by overcoming traditional prospective birth cohort limitations and providing evidence-based understanding of how environmental chemical exposures during sensitive developmental periods influence neurodevelopmental trajectories into adolescence.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $815.5k | 6/23/26 |