This $728,408 Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to biologically validate novel genetic variants associated with increased susceptibility to pesticide-induced Parkinson's disease.
The research will utilize two complementary systems - induced pluripotent stem cell-derived human dopaminergic neuronal cultures and a mouse model of paraquat-induced parkinsonism - to evaluate the effects of up-regulating and down-regulating candidate genes on markers of oxidative stress and susceptibility to pesticide toxicity.
A subaward to the Northern California Institute For Research And Education, Inc. (Ncire) will contribute to this research, which is expected to identify novel genetic factors that influence dopaminergic susceptibility to environmental pesticide exposures. The program seeks to establish a platform for evaluating additional candidate genes and toxicants in relation to Parkinson's disease risk.
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