The National Institute of Environmental Health Sciences (NIEHS) awarded a $637,553 Project Grant under the Environmental Health (CFDA 93.113) program to Rutgers, The State University of New Jersey, doing business as RBHS-School of Nursing. This 5-year grant, running from July 2024 through June 2029, will fund research to assess the intestinal uptake, translocation, biodistribution, and toxicity of ingested environmentally relevant micro-nanoplastics (MNPs) and the role of inflammation in these processes. The research will utilize advanced cellular and in vivo models to characterize the properties of MNPs, evaluate their interactions with intestinal epithelial cells and organoids, and investigate MNP biodistribution and toxicity in healthy and inflammatory bowel disease-susceptible mouse models. The findings from this study are expected to inform risk assessments and guide future research on the potential human health impacts of ubiquitous environmental MNP exposures.