This $561,584 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will support research to investigate the ovarian disrupting effects of per- and polyfluoroalkyl substances (PFAS) on female reproductive health. The project aims to use in vivo, in vitro, and in silico models to test the hypothesis that PFNA, a major PFAS compound, acts primarily through the peroxisome proliferator-activated receptor gamma (PPARG) pathway to interfere with ovarian folliculogenesis and ovulation, leading to impaired female fertility. The research will also explore the ovotoxicity of other PFAS of public health concern and their mixtures. This innovative and significant work is expected to elucidate the underlying mechanisms of PFAS-induced ovarian toxicity, enabling the development of prevention, mitigation, and remediation methods to protect female reproductive health. The project will be conducted by Rutgers, The State University of New Jersey, with an award period running from December 2024 through October 2029.
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