Project Grant R01EB037012
- This Project Grant award of $404,032 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a machine learning-powered platform for the discovery of peptide ligands for peptide-drug conjugates (PDCs). The key objective is to create a next-generation peptide discovery system capable of identifying PDC leads within 3 months. The platform will utilize a peptide array designed for enhanced protease...
- This federal Project Grant award of $427,625 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Washington (UW). The project aims to develop a novel nano-prodrug delivery platform that targets microbiome-modulating molecules to the distal gastrointestinal tract, and integrate physiologically-based pharmacokinetic (PBPK) modeling with pharmacomicrobiomics. The key objectives...
- This $616,523 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to advance phenotypic drug discovery (PDD) by developing a generative AI-driven platform for cell morphology-guided, scalable, and controllable small molecule design without relying on drug targets. The key products to be delivered under this 3-year award...
- This federal Project Grant award, valued at $375,337.00 and provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of photothermal mid-infrared single molecule super-localization microscopy to track the intracellular processes governing mRNA release from lipid nanoparticle (LNP) formulations. The goal is to provide...
- This Project Grant award of $384,896.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel peptide-based biomaterials that can directly modulate cell and tissue responses. The goal is to create advanced biomodulatory materials, such as self-adjuvanting vaccines, anti-inflammatory therapeutics, cell-targeted cancer therapies, and bone regenerative products, to address challenges in...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $1,812,356.00 to The University of Texas MD Anderson Cancer Center (MD Anderson) to develop a rapid, inexpensive microfluidics-based approach for dose-on-demand production of human dosage quantities of ready-to-inject radiopharmaceuticals. The project aims to...
- This $350,027 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is for the development of a cost-effective, efficient, and generalizable water-based PLGA microsphere encapsulation technology for delivering commercial peptide drugs via monthly injections. The project aims to formulate and optimize sterile remote-loaded PLGA microspheres that can provide constant delivery of peptide drugs,...
- The federal Project Grant award of $673,600.00 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop an RNA-based sensor that can detect changes in both mRNA and miRNA within living cells and mouse models. The objective is to create a programmable, synthetic biology tool that can identify diseased cells based on their RNA profiles and trigger...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $375,633 project grant to the University of Nevada, Las Vegas (UNLV) to develop an enhanced lipid nanoparticle (LNP) platform for selective and improved delivery of therapeutics in vivo. The key objectives are to: 1) investigate how LNP interactions with endogenous systems can be leveraged to redesign and improve delivery systems; and 2) examine how...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $122,577 to Trustees of Boston University for the development and characterization of self-amplifying RNA lipid nanoparticles. The goal is to create a platform that can sustainably and simultaneously deliver multiple immunostimulatory and gene therapy payloads directly to solid tumors, which account for nearly 90% of adult cancers and are difficult to treat effectively. The project aims to...
This federal Project Grant award of $662,913 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a universal drug delivery platform using peptide amphiphiles (PAs). The research will exploit the dynamic interactions of PAs with lipid-containing biomolecules, such as lipoproteins and lipid rafts, to target a broad range of solid tumors. Through preliminary experiments, the PAs have demonstrated strong accumulation in various tumor models in mice and rats. The grant period runs from August 1, 2025 to July 31, 2029, and the work will be conducted by the Oregon Health & Science University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $662.9k | 7/29/25 |