Project Grant R01EB036562

Award Date 7/1/25
Completion Date 3/31/29
Dollars Obligated $616K
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) provides $666,670 to The Trustees of the University of Pennsylvania to develop innovative scan protocols that combine long axial field-of-view PET and spectral CT imaging for improved quantification in oncology. The goal is to create methods and protocols to obtain high-quality dynamic information from both PET and CT modalities, and to use dynamic spectral CT for PET...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the federal Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is funding the development of a laparoscopic probe prototype designed for detecting 511 keV gamma rays from PET tracers. The key products to be delivered include: Improving an initial larger-diameter prototype by testing different geometries and materials to optimize the...
This $536,954 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will fund research and development of a novel ultra-high-spatial resolution computed tomography (UHR-CT) system using photon-counting detectors and multiple x-ray focal spots. The research aims to overcome limitations of current high-resolution CT systems by developing...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $502,841 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to The Regents of the University of California, operating as Lawrence Berkeley National Laboratory (LBNL). The funding will support research and development of a novel detector readout concept for monolithic scintillation detectors that enables direct digitization...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA program "Discovery and Applied Research for Technological Innovations to Improve Human Health" (93.286), will fund the development of a novel real-time interactive Positron Emission Tomography (PET) and Ultrasound (US) imaging technology. The goal is to enable interactive PET and US scanning with real-time visualization of molecular contrast fused with US images to...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development and optimization of a modular time-of-flight (TOF) positron emission tomography (PET) prototype scanner. The goal is to create a flexible PET system with an extended axial field of view over 1 meter, which can enable faster and more cost-effective...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program, provides $641,063 to develop a dynamic, customizable, vendor-neutral patient projection data library and virtual imaging trial (VIT) software platform (DICOM-CTPD-VIT). This platform will enable the generation of a diverse range of imaging conditions, including...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $719,124 Cooperative Agreement under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The Johns Hopkins University on July 15, 2025. The project aims to develop the next generation of photon counting detectors (PCDs) with multi-energy inter-pixel coincidence counter (MEICC) and digital pulse energy correction (DPEC) functionality for X-ray computed...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $1,722,700.00 to Yale University to acquire a state-of-the-art preclinical PET/CT imaging system. The new system will enhance preclinical imaging research capabilities at the Yale PET Center, supporting 19 NIH-funded investigators conducting PET imaging research across various medical disciplines. The award aims to replace an end-of-life PET-only system and...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $762,697.18 to support research at the University of Pennsylvania focused on developing new radiofluorination methods to rapidly access fluorine-18 labeled organic molecules for PET imaging agents. The key objectives are to: 1) optimize a protocol for amide...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $616,033 to the University of California, Davis to develop and validate a PET-enabled dual-energy CT (DECT) imaging method. The goal is to create a technique that can derive a high-energy gamma-ray CT (GCT) image from standard PET/CT emission data, and combine it with low-energy X-ray CT to enable quantitative material decomposition on PET/CT scans. This innovative approach aims to expand the capabilities of PET/CT molecular imaging without requiring changes to existing scanner hardware or increasing radiation dose. The project has three specific aims: (1) develop the technical approaches for GCT imaging with PET, (2) evaluate the PET-enabled DECT method for material decomposition in human subjects, and (3) apply the method for metabolic PET quantification of bone marrow. Successful completion of this award from July 2025 to March 2029 would establish a new PET-enabled DECT imaging technique with broad applicability in areas like contrast-enhanced PET/CT and bone-marrow PET/CT imaging.

Generated 8/5/25, 6:32 AM