This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $616,033 to the University of California, Davis to develop and validate a PET-enabled dual-energy CT (DECT) imaging method. The goal is to create a technique that can derive a high-energy gamma-ray CT (GCT) image from standard PET/CT emission data, and combine it with low-energy X-ray CT to enable quantitative material decomposition on PET/CT scans. This innovative approach aims to expand the capabilities of PET/CT molecular imaging without requiring changes to existing scanner hardware or increasing radiation dose. The project has three specific aims: (1) develop the technical approaches for GCT imaging with PET, (2) evaluate the PET-enabled DECT method for material decomposition in human subjects, and (3) apply the method for metabolic PET quantification of bone marrow. Successful completion of this award from July 2025 to March 2029 would establish a new PET-enabled DECT imaging technique with broad applicability in areas like contrast-enhanced PET/CT and bone-marrow PET/CT imaging.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $616.0k | 7/1/25 |