Project Grant R01EB035594

Award Date 8/1/24
Completion Date 4/30/28
Dollars Obligated $327K
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Ohio, USA
Similar Awards
This $257,807 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health") will support the development of living biosensors for detecting and analyzing DNA at the single-base level, without requiring sample purification or specialized equipment. The proposed biosensors will use natural bacterial competence and CRISPR-Cas systems to pull DNA from...
This $1,165,298 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to develop novel nanopore- and click-chemistry-based approaches for rapid, culture-independent detection of sepsis-causing pathogens directly from blood samples. The 5-year project, starting on July 1, 2024, will engineer nanopore biosensors and multiplex click chemistry assays capable of detecting sepsis-causing protein...
This $1,200,000 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of innovative sensing technologies that integrate DNA nanotechnology and CMOS electronics for next-generation diagnostics. The key objectives of this 4-year project are to: 1) develop molecular engineering techniques for in-situ signal amplification of aptamer biosensors using DNA origami nanotechnology; 2)...
This $447,747 Project Grant award from the National Science Foundation (NSF) Engineering Program (CFDA 47.041) to Trustees of Boston University will develop a novel plasmonic nanosensor system to detect two important classes of RNA molecules - microRNA (miRNA) biomarkers and SARS-CoV-2 viral RNA. The sensor platform uses DNA structures with nanoparticle probes that undergo conformational changes when binding to target RNAs, altering the plasmonic coupling signal which is detected via...
The federal Project Grant award of $249,000 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program, supports the development of a novel split enzyme diagnostic platform for rapid, sensitive detection of biomarkers at the point of care. The key objectives are to: Incorporate binding domains into a split adenylate cyclase system to detect clinically...
This $788,406 project grant from the National Institutes of Health National Institute of Allergy and Infectious Diseases, under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund the development of a sensitive, direct reading bioaerosol detection platform to quantify airborne pathogens such as SARS-CoV-2. Aerosol Devices Inc. will integrate their gentle condensation-growth capture sampler, which concentrates intact, viable virus particles into a small liquid volume...
This National Science Foundation (NSF) CAREER grant, under the Engineering program (CFDA 47.041), provides $242,687 to the University of Massachusetts for the development of an ultrasensitive nanopore biosensor technology for point-of-care detection of infectious disease biomarkers. The project aims to enable rapid, accurate, and low-cost quantification of multiple biomarkers from human blood samples, addressing the limitations of current point-of-care testing technologies. Key objectives...
This $960,000 National Science Foundation project grant supports the development of a multiplexed plasmon-enhanced lateral flow assay for point-of-care detection of SARS-CoV-2 RNA and antigens. Funded under the NSF Engineering program (CFDA 47.041), the grantee, Washington University, will design, validate and build a novel diagnostic platform with sensitivity exceeding standard laboratory tests. Key deliverables include an ultrasensitive multiplexed lateral flow assay for simultaneous...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is developing a microfluidic device for rapid and inexpensive pathogen detection in rodent animal health surveillance. The goal is to create a device that can be used cage-side to complement existing quarterly room/rack monitoring, enabling faster outbreak mitigation and health status confirmation for animal importation. The key...
This $349,566 Project Grant award from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of Biosensing Instrument Inc.'s Spotting-Free Nano-Oscillator Array (SFNOA) technology. The SFNOA system aims to provide high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. Key innovations include the use...

This $326,944 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering, under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program, aims to develop a deployable and adaptable plasmonic sensing platform for cost-effective, sensitive, and accurate point-of-need infectious disease testing.

The grant will fund the development of catalytic surface-enhanced Raman scattering (SERS) sensors based on functional DNA sequences. These sensors are intended to provide highly multiplexed assays to improve accuracy in pathogen and variant identification, as well as enable quantifiable viral load determination. The project also plans to create an automated sensor design algorithm and lyophilized sensing tablets to enable practical, on-demand point-of-need testing. The sensing platform will be validated through a multiplexed assay to detect SARS-CoV-2 and its variants in saliva samples. The award period is from August 1, 2024 to April 30, 2028.

Generated 4/8/25, 5:23 AM