The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Yale University a $348,595 grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program. The purpose of this 4-year Project Grant (R01EB035093) is to develop an improved framework for quantifying drug efficacy and target engagement using positron emission tomography (PET) imaging. The framework will jointly estimate spatial receptor occupancy maps and a global effective concentration (EC50) map, leveraging advanced optimization strategies to enhance precision over conventional methods. This work aims to reduce sample size requirements or increase statistical power for drug trials by improving the estimation of key pharmacokinetic parameters. The project will be validated through numerical simulations and in vivo animal studies.
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