The University of Texas Southwestern Medical Center received a $497,982 Project Grant award under the National Institutes of Health's Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program. The grant will support the development of an Intra-Treatment Dynamic Imaging and Plan Adaptation (IDIPA) system to improve the accuracy of lung radiotherapy delivery under patient motion. The IDIPA system consists of two key components: 1) a Spatial and Temporal Implicit Neural Representation (STINR) sub-system that reconstructs dynamic cone-beam CT images and deformation vector fields from x-ray projections, and 2) a Dosimetry-Guided Plan Adaptation (DGPA) sub-system that uses the reconstructed imaging data to calculate delivered radiation doses and adapt future treatment plans. The overarching goal is to systematically address the challenge of intra-treatment tumor and organ motion in stereotactic body radiation therapy for lung cancer, enabling highly precise dose delivery while minimizing radiation-induced toxicity. The project will run from June 2024 through March 2028.