Project Grant R01DK148909
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Beckman Research Institute of the City of Hope $307,108 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on alpha cell heterogeneity in Type 1 Diabetes. The funded research will investigate functional heterogeneity within pancreatic alpha cell subpopulations and their regulatory interactions with neighboring beta and delta cells...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $782,890 on August 15, 2026, for Project Grant R01DK148505 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research examines how alpha cells in the pancreas regulate glucose through distinct and sometimes opposing mechanisms during obesity and weight loss. Alpha cells overproduce glucagon in obesity and insulin resistance,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of the City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct three-dimensional spatial and translational profiling of stress response pathways in Type 1 Diabetes. The research examines how proinflammatory cytokines activate the integrated stress response in pancreatic beta cells during early Type 1...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Florida $754,682 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate beta cell dysfunction in type 1 diabetes through glucose metabolism studies in human pancreatic tissue. The research addresses mechanisms of beta cell failure by examining glucose sensing and insulin secretory pathway components altered during type 1 diabetes...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $248,975 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is a Project Grant. The research investigates pancreatic beta-cell dysfunction triggered by chronic high glucose, with focus on mRNA translation defects and their role in type 1 diabetes...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of The City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how the native pancreatic microenvironment regulates human islet cell function in health and type 1 diabetes. The research employs human pancreatic tissue slices to preserve native cellular architecture and directly compares hormone...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Texas Health Science Center at Houston $149,264 on April 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the transcription factor GA-binding protein (GABP) in pancreatic beta cell survival and turnover. The research uses beta cell-specific GABPA knockout mice to define GABP's function in beta cells, with the long-term goal...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $868,670 to Beckman Research Institute of the City of Hope on February 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research on beta cell regeneration therapy for type 1 diabetes. The research investigates synergistic combinations of DYRK1A inhibitors, GLP-1 receptor agonists (specifically exenatide), and low-dose interleukin-2 to...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California Irvine $132,423 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant K01DK143200) to investigate the role of basonuclin 2 (BNC2) neurons in glucose regulation and diabetes treatment. The research elucidates how BNC2 neurons, a previously uncharacterized population of leptin receptor-expressing neurons within the...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) was awarded $3,140,632 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for a four-year project period from September 1, 2025, through August 31, 2029. This Project Grant supports fundamental biomedical research focused on elucidating the mechanisms of human endocrine lineage commitment...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, San Diego $501,246 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate alpha-beta cell communication and functional heterogeneity of beta cells in type 2 diabetes. The project, led by principal investigator Vira Kravets, PhD, examines how paracrine signaling from alpha cells—primarily through GLP-1 receptor and glucagon signaling—creates spatial microenvironments that reprogram neighboring beta cells metabolically and transcriptionally. The research addresses three knowledge gaps: the role of alpha-cell-mediated GLP-1R signaling in shaping beta cell heterogeneity, the effect of beta cell proximity to alpha cells on local gene expression, and the selective vulnerability of functionally distinct beta cell subpopulations ("first responders" and "leaders") to type 2 diabetes dysfunction. Aim 1 employs optical calcium imaging, phasor-FLIM NAD(P)H readouts, and PKA sensors in live human and mouse pancreatic slices to quantify how GLP-1R and downstream PKA signaling contribute to beta cell heterogeneity. Pharmacological blockade and transgenic models will test GLP-1R and glucagon receptor signaling roles; in-silico modeling will complement experimental findings. Aim 2 combines functional imaging with spatial transcriptomics in pancreatic slices from non-diabetic and type 2 diabetes donors to define the alpha cell role in shaping beta cell subpopulations preferentially vulnerable in disease. Work is performed in La Jolla, California, with a period of performance from September 1, 2026, through August 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $501.2k | 9/2/26 |