Federal Grant Award Summary

Stony Brook University, through The Research Foundation For The State University Of New York, received a $615,508 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, effective May 2, 2026, through February 28, 2031, supports fundamental biomedical research investigating the role of plasmalemma vesicle associated protein (PLVAP) in glomerular endothelial cell injury across glomerular diseases, with particular focus on thrombotic microangiopathy (TMA). The research employs advanced analytical methods including single nucleus RNA sequencing, immunostaining, transmission electron microscopy, and in vitro molecular studies to elucidate mechanisms of glomerular endothelial cell dysfunction, identify therapeutic targets, and characterize the transcriptional regulation of PLVAP expression in injured cells.

The project deliverables encompass comprehensive research findings on PLVAP's role in glomerular filtration rate loss and kidney disease progression, identification of potential regulatory mechanisms through transcription factor analysis, and development of molecular insights that may inform prevention and treatment strategies for glomerular diseases. By advancing understanding of how glomerular endothelial cells respond to injury and the pathological mechanisms underlying kidney disease, this research directly aligns with NIDDK's mission to improve understanding and treatment of kidney diseases and related metabolic disorders.