Project Grant R01DK145925
- Federal Project Grant Award Summary Award Overview Indiana University Indianapolis received a $811,217 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded February 18, 2026, with completion targeted for January 31, 2031. The award supports fundamental research on signaling mechanisms of ultra-stable single-chain insulin (SCI) analogs and...
- Federal Grant Award Summary Indiana University Indianapolis received a $480,697 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective March 1, 2026 through February 28, 2031. The award funds basic biomedical research investigating the role of Sestrin3 (SESN3) protein in protecting against metabolic dysfunction-associated steatohepatitis...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $244,596 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded June 17, 2025, with completion anticipated December 16, 2026. The award funds basic biomedical research investigating cilia-mediated proliferation in hypothalamic tanycytes and the role of Hedgehog signaling in...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Indiana University Indianapolis $145,648 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on June 19, 2026, with a completion date of December 31, 2027. This National Research Service Award (NRSA) provides predoctoral research training and career development support for Ms. Hibbard to investigate the role of fibroblast activation protein...
- Federal Grant Award Summary Indiana University Indianapolis received a $237,750 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with completion targeted for August 31, 2027. This R03 award funds a qualitative research study examining nephrology practices' participation decisions and care model reforms under Medicare's...
- Federal Project Grant Award Summary Award Details: Microvascular Tissues, Inc. received a $700,000 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for the period of September 17, 2025 through August 31, 2026. The research will be conducted at the company's facility in San Diego, California. Products and Services: The project involves evaluating the efficacy...
- Federal Project Grant Award Summary The University of Michigan received a $531,280 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded on June 18, 2025, with completion targeted for December 31, 2027. This award supports postdoctoral research training and investigation into the mechanisms of Notch signaling in intestinal stem cells (ISCs), with...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Pennsylvania a $798,039 Project Grant effective March 1, 2026, through January 31, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research initiative will deliver computational modeling and experimental research aimed at understanding self-organization mechanisms in the intestinal epithelium, specifically...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,390,830 Project Grant to the University of California, San Francisco (UCSF) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) effective September 1, 2025, through August 31, 2029. This award funds the development of scalable and transplantable pancreatic islet organoids with engineered oxygenation to improve therapeutic...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $157,000 Project Grant to Michigan State University (in partnership with Henry Ford Health) beginning May 1, 2026, and concluding April 30, 2028, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds development of targeted nanotheranostics designed to protect pancreatic beta-cells in Type 1 Diabetes (T1D). The research...
Award Details: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $813,999 Project Grant to Indiana University Indianapolis on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The five-year project will conclude on February 28, 2031. Products and Services: This award funds the development and preclinical evaluation of Stem Cell Impregnated Thread Reinforced Encapsulation Devices (THREDs), a novel therapeutic delivery system designed to treat acute and chronic mesenteric ischemia. The investigator will deliver three primary research products: (1) a cellular delivery system that deploys hydrogen sulfide (H2S) from vertebral body-derived mesenchymal stem cells (VB-MSCs) to enhance mesenteric blood flow; (2) preclinical studies evaluating the interaction between encapsulated VB-MSCs, H2S, and nitric oxide in promoting chronic mesenteric vasodilation and intestinal adaptation; and (3) final preclinical testing in a porcine model to assess scalability and effectiveness of the THRED-packaged VB-MSC system. The research combines basic science investigation with translational applications to establish proof of concept for an implantable, retrievable device that protects stem cells from immune rejection while enabling therapeutic paracrine factor release.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $814.0k | 5/1/26 |