Project Grant R01DK145923
- Summary Oregon Health & Science University (OHSU) received a $1,329,538 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 1, 2025, with a completion date of April 30, 2030. The project focuses on developing genetically enhanced allogeneic hepatocytes for transplantation without requiring immunosuppression. OHSU will conduct three...
- Federal Grant Award Summary Oregon Health & Science University received a $234,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with completion targeted for August 31, 2027. The award funds basic biomedical research to decipher the molecular mechanisms by which the mRNA-binding protein IMP1 (Insulin-like...
- Federal Project Grant Summary Oregon Health & Science University received a $1,421,456 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) effective September 1, 2025, through June 30, 2030. The award supports basic biomedical research investigating cellular heterogeneity and function in specific kidney tubule segments, including the thick ascending limb...
- Federal Grant Award Summary The University of Oregon received a $245,686 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective June 23, 2025, with a completion date of December 31, 2027. The award funds basic biomedical research investigating the molecular mechanisms by which Beta-Cell Expansion Factor A (BEFA), a secreted bacterial protein,...
- Federal Grant Award Summary The University of Oregon received a $2.57 million Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 10, 2025, with completion scheduled for August 31, 2027. This award funds basic biomedical research investigating the mechanism and therapeutic potential of BEFA (beta-cell expansion factor A), a...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded UCLA a $786,216 project grant effective August 28, 2025, through June 30, 2029, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research investigating post-transcriptional regulation of hepatokines—secreted liver peptides that coordinate systemic metabolism—and their role in metabolic homeostasis. The research employs...
- Federal Project Grant Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Leland Stanford Junior University a Project Grant of $2,736,640 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on September 5, 2025, with a completion date of September 4, 2029. This four-year research initiative focuses on characterizing the genetic variation underlying innate lymphoid cell (ILC) phenotypes and their role in...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $173,664 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded August 7, 2025, with a completion date of July 31, 2030. This award supports research aimed at developing a comprehensive molecular characterization of ascites fluid in patients with decompensated...
- Federal Project Grant Award Summary Renovate Biosciences Inc. received a $584,232 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 25, 2025, with completion targeted for August 31, 2026. The award supports the BLIPS (Biocompatible Liver in Pigs) project, which aims to develop xenotransplantation technology using pigs as...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Utah a $729,085 Project Grant effective September 1, 2025, through June 30, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research project investigates the mechanisms of mitochondria-driven hepatocyte injury, with a focus on the EF-hand domain family member D1 (EFHD1) protein and its role in...
Oregon Health & Science University (OHSU) received a $686,129 project grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective January 16, 2026, with completion targeted for November 30, 2029. The award supports research on intraductal gene therapy for liver cirrhosis, an investigator-initiated biomedical research project aimed at improving treatment options for advanced liver disease. Under this award, OHSU will systematically explore the intraductal route of gene therapy administration as an alternative to conventional systemic delivery methods. The research will evaluate two primary gene therapy modalities—recombinant adeno-associated virus (rAAV) vectors in Aim 1 and RNA nanoparticles in Aim 2—with the objective of demonstrating improved biodistribution profiles, reduced off-target effects, lower effective dosing requirements, and successful hepatic transduction in cirrhotic liver conditions. The study will test the delivery of insulin-like growth factor-1 (IGF-1) to cirrhotic rats to validate the clinical utility of the intraductal approach for treating liver cirrhosis.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $686.1k | 1/16/26 |