Project Grant R01DK145538
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University $140,396 on December 13, 2025, for research investigating the role of PDX1 C-terminal interaction domains during pancreatic endocrine differentiation and proliferation under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research examines how the homeobox transcription factor PDX1 regulates insulin-producing beta cell development and proliferation in the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Northwestern University $747,256 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to define the role of lymphatics in pancreatitis pathogenesis. The recipient will conduct research using mouse models, single-cell RNA sequencing, advanced imaging, and bioinformatics analyses to define functional roles of lymphatics in both acute and chronic pancreatitis...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $175,000 on May 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct spatial profiling of pancreatic N-glycosylation in type 1 diabetes. The research employs state-of-the-art imaging technologies to map how protein N-glycosylation—the enzymatic attachment of complex carbohydrate chains to asparagine residues on...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $197,600 on September 30, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the regulation of exocrine pancreatic innate immunity via microbially induced interleukin-22 (IL-22). The research establishes the role of gut microbes in modulating pancreatic IL-22 and the consequences of the gut-to-pancreas axis on pancreatic health...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Iowa $655,482 on March 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the Notch signaling pathway in chronic pancreatitis pathogenesis. The project focuses on elucidating how Notch pathway activation in pancreatic stellate cells drives fibrogenesis and immune modulation in chronic pancreatitis, a fibro-inflammatory...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Brigham & Women's Hospital Inc. $730,898 on July 10, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate NR5A2 regulatory mechanisms in pancreas health and disease. The research examines how the transcription factor NR5A2 governs acinar cell identity and its role in preventing acinar-to-ductal metaplasia, a reversible process occurring during acute...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Alabama at Birmingham $718,880 on August 10, 2026, to investigate pancreatic regeneration in conditions caused by genetic mutation under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research develops and utilizes a novel animal model that mimics pancreatic injury and healing in individuals with cystic fibrosis caused by a specific CF gene mutation. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $484,720 on June 22, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate ferroptotic damage mechanisms in acute pancreatitis and develop therapeutic interventions. The award funds basic and translational research into how the autophagy receptor SQSTM1 sensitizes pancreatic acinar cells to ferroptosis—a...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University $140,644 on December 13, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify mechanisms of T follicular helper and germinal center B cell pathogenicity in type 1 diabetes. The research examines how T follicular helper cells and germinal center B cells interact to drive autoimmune destruction of pancreatic beta cells in type 1 diabetes....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Cincinnati Children's Hospital Medical Center $824,078 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize drug-induced pancreatic injury using integrated computational, real-world evidence, and systems pharmacology approaches. The research project will employ computational methods to analyze pancreatitis transcriptomic signatures and perturbagen...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University $780,890 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how tuft cells resolve pancreatic injury through type 2 immune signaling in chronic pancreatitis. The research examines the role of chemosensory tuft cells that form during acinar-to-ductal metaplasia in chronic pancreatitis. The study tests the hypothesis that tuft cells secrete prostaglandin D2 (PGD2) and IL-25 to induce a tissue-restorative type 2 immune response, creating a protective niche that reduces injury severity and accelerates healing. The project addresses a critical gap: current management of chronic pancreatitis—a progressive inflammatory disease leading to exocrine insufficiency, malnutrition, diabetes, and increased pancreatic cancer risk—is limited to risk-factor modification, pain control, and supplementation of failed endocrine and exocrine function, with surgery offering no cure. Preliminary data demonstrate that chronic pancreatitis is characterized by type 2 cytokines (IL-13, IL-25, IL-33) and immune cells, and that ablation of either tuft cells or IL-25 exacerbates tissue injury. The award is a Project Grant with a period of performance from September 1, 2026, to May 31, 2030. Work is performed in Nashville, Tennessee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $780.9k | 8/28/26 |