Project Grant R01DK145097
- This $223,176 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to characterize the role of apolipoprotein L1 (APOL1) copy number variations (CNVs) in kidney disease susceptibility among African Americans. The research, conducted by Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA, aims to: 1) develop a computational...
- This federal Project Grant award for $829,985 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the University of Virginia to develop new Drosophila, mouse, and human podocyte models to study the interaction between HIV, APOL1 risk alleles (G1 and G2), and chronic kidney disease in people living with HIV. Key objectives include...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $739,540 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of Columbia University in the City of New York for the development and validation of a third-generation polygenic score (GPS) for chronic kidney disease (CKD). The goal is to improve personalized risk prediction and accelerate the clinical implementation of polygenic prediction in...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This federal Project Grant award of $342,002.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at Western Michigan University Homer Stryker M.D. School of Medicine (WMED) to develop novel cellular tools for studying the regulation of the PKD1 gene in autosomal dominant polycystic kidney disease (ADPKD). The research aims to...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $231,270 to The Trustees of Columbia University in the City of New York to conduct large-scale rare variant analyses across major biobanks involving 1 million participants. The goal is to identify rare genetic variants and genes associated with chronic kidney disease (CKD), as well as develop and integrate...
- This Project Grant award of $277,089, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to improve understanding of the genetic drivers of nephrotic syndrome (NS) in order to guide clinical management and develop targeted therapies. The research, conducted by The Children's Hospital Corporation (dba Boston Children's Hospital), will investigate the...
- This $243,750 Project Grant was awarded on September 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of the protein DCLK1 in regulating the DNA damage response in proximal tubule cells, which are important mediators of chronic kidney disease (CKD). The research aims...
- This Project Grant award of $830,500.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research investigating the role of glycosphingolipids in kidney disease associated with diabetes and obesity. The key objectives are to: Test whether inhibiting glucosylceramide synthesis in podocytes, renal tubules, or the immune system can prevent progression of kidney disease in mouse...
This $659,358 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) investigating the genetic and biological mechanisms underlying kidney disease associated with APOL1 risk variants, particularly focused on the relationship between APOL1 gene dose and kidney pathology, the role of APOL1 protein multimerization in cytotoxicity, and how interferon signaling impacts these processes. The research aims to provide critical insights into the recessive, gain-of-function toxicity of APOL1 risk variants that drives disproportionately high rates of kidney disease in people of African ancestry. The award has an initial period of performance from September 2025 through June 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $659.4k | 9/4/25 |