Project Grant R01DK144611
- This federal Project Grant award of $813,511 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the Dana-Farber Cancer Institute, Inc. (DFCI) to investigate the structural basis and functional consequences of thermogenic mitochondrial respiratory complexes assembly in the context of obesity and type 2 diabetes. The research aims to...
- This Project Grant award of $223,176 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a research project titled "The Contribution of Mitochondrial DNA Damage to Diabetes-Related Beta-Cell Failure". The award, which runs from December 27, 2024 to August 31, 2026, provides funding for Dr. Rebecca Davidson, a postdoctoral research fellow at the University of Michigan, to...
- This federal Project Grant award of $803,748 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding research to investigate the modulation of insulin signaling in adipocytes (fat cells) and how improved adipocyte insulin sensitivity can contribute to positive metabolic outcomes. The research team at The University of Texas Southwestern Medical...
- This $2,971,227 federal Project Grant, awarded on September 4, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of fatty acids in regulating cellular metabolism and protein synthesis in the context of fasting, inflammation, and metabolic diseases. The research aims to uncover novel signaling pathways through which fatty...
- This federal Project Grant award in the amount of $1,428,186.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts. The project aims to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, which has implications for understanding the early...
- This $2,638,760.00 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research aims to investigate a novel mechanism involving the metabolite rhodoquinone (RQ) and its potential role in improving mitochondrial function and mitigating metabolic diseases caused by obesity. Specifically, the project will elucidate how the RQ/fumarate...
- This federal Project Grant award of $464,985, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on extracellular vesicles released by adipocytes (fat cells) and their potential role in cardiometabolic disease. The research, conducted by The Washington University, aims to investigate how these adipocyte-derived extracellular vesicles, including...
- The federal Project Grant award of $2,107,630 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a longitudinal study to assess insulin vesicle functional capacity, beta cell mass, and pancreas volume in individuals at risk for and with recent onset type 1 diabetes. The study aims to utilize PET and MRI techniques to provide a comprehensive picture of beta...
- This federal Project Grant award of $194,966 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a research project led by Dr. Joshua Cook at Columbia University's Health Sciences Division to investigate the pathophysiology of selective insulin resistance in humans. Specifically, the project aims to demonstrate that high insulin levels continue...
- This federal Project Grant award of $1,620,238 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund a research project at the University of North Carolina at Chapel Hill (UNC-CH) to detect regulatory variants and elements at type 2 diabetes genetic association signals across multiple tissues, including pancreatic islets, adipose, skeletal...
This federal Project Grant award of $672,737 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of mitochondria in dysregulated insulin secretion in obesity, which can lead to the development of type 2 diabetes. Specifically, the research aims to characterize the molecular determinants of fatty acid-induced insulin secretion (FASIS) and its contribution to type 2 diabetes progression. The project will examine how mitochondrial fragmentation in beta cells, induced by exposure to high fat, impacts fatty acid oxidation and fuel preference, ultimately leading to aberrant insulin secretion. The award has an August 2025 start date and is scheduled for completion by July 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $672.7k | 8/7/25 |