Project Grant R01DK143918
- This $243,750 Project Grant was awarded on September 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of the protein DCLK1 in regulating the DNA damage response in proximal tubule cells, which are important mediators of chronic kidney disease (CKD). The research aims...
- The Department of Health and Human Services National Institutes of Health (NIH) awarded Duke University a $1,425,761 Project Grant under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The purpose of this 3-year award is to harness stem cells and synthetic gene circuits to repair glomerular injury and address the significant burden of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in the U.S. and worldwide. The research will leverage Duke's expertise in...
- This federal Project Grant award of $168,886 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to elucidate the role of NAD+ and PARP1 in nephron endowment and kidney development. The 5-year project, awarded on May 1, 2025 with a completion date of January 31, 2030, will be conducted by the University of Texas Southwestern Medical Center. The...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This $128,286 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research into the mechanisms of renal lipotoxicity and its contribution to the development of chronic kidney disease (CKD). The principal investigator will investigate the protective role of the FAF2 gene knockout in mitigating palmitate-induced lipotoxicity in...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $882,138 Project Grant to Mayo Clinic under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "NEXT GENERATION KUH RESEARCHERS (GENERATOR) TRAINING CORE", will fund a research and career development program focused on predoctoral and postdoctoral scholars in kidney, urologic, and hematologic (KUH) research. The 5-year project aims to create a...
- This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the molecular mechanisms driving the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). The $1,491,303 award to The Washington University aims to characterize how the repression of the FOXM1-CCNF axis during tubular epithelial...
- This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
- The University of Southern California (USC) was awarded a $445,870 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, which runs from Sep 2, 2025 to Sep 1, 2027, will be used to develop a spatially patterned, mature, and functional human kidney organoid model by leveraging the plasticity of kidney progenitor cells. The goal is to overcome...
- This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to identify the progressive compositional, regulatory, and spatially defined signaling environments in mid to late-gestation primate nephrogenesis. The $240,978 award, granted to the Children's Hospital Medical Center in Cincinnati, Ohio, aims to leverage the...
This Project Grant award of $633,272 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Tulane University to investigate the epigenetic mechanisms driving the lifespan and differentiation of nephron progenitor cells, with the goal of improving understanding and potential therapeutic approaches for renal regeneration. The comprehensive 5-year research plan combines advanced multi-omics, epigenomics, and mouse genetics to dissect the complex regulation of nephron progenitor cell lifespan. The research team at Tulane University will leverage their expertise in biomedical research, advanced laboratories, and interdisciplinary capabilities to conduct this innovative investigation addressing critical challenges in kidney biology and regeneration.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $633.3k | 9/23/25 |