Project Grant R01DK143088
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $200,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Washington University in St. Louis. The goal of this R56 award is to delineate the molecular mechanism regulating autophagy in Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) caused by UMOD mutations. The university will use CRISPR/Cas9 technology to generate the first...
- This $829,985 Project Grant was awarded on July 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Virginia to develop new Drosophila, mouse, and human podocyte models to study the interaction between HIV and APOL1-G1, a genetic risk factor associated with increased risk of HIV-related chronic kidney disease...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $404,883 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Washington. The award will fund a 2-year project to optimize a high-resolution spatial transcriptomics assay called Pixel-SeqV2 for analyzing gene expression in kidney tissue at single-cell resolution. The project will also develop a new integrated spatial multi-omics...
- The Department of Health and Human Services National Institutes of Health (NIH) awarded Duke University a $1,425,761 Project Grant under the Trans-NIH Research Support (CFDA 93.310) federal grant program. The purpose of this 3-year award is to harness stem cells and synthetic gene circuits to repair glomerular injury and address the significant burden of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) in the U.S. and worldwide. The research will leverage Duke's expertise in...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $661,694 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on understanding the non-canonical role of the FANCD2 protein in kidney development and repair. The key products and services to be delivered through this...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,967,657 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Mayo Clinic Jacksonville, a nonprofit organization. The grant supports a 4-year research project to investigate the role of urinary urate in regulating water homeostasis and suppressing cyst formation in autosomal dominant polycystic kidney disease (ADPKD). Key objectives include...
- The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $109,076 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Weill Medical College of Cornell University. The grant supports research to determine the structural basis of allosteric communication in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, investigate mechanisms of CFTR pharmacological inhibition, and identify new...
- The Project Grant award for "The Role of HNF4A in CKD" was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $799,952 award, granted on September 1, 2025, supports research to investigate the role of the protein HNF4A in the progression of chronic kidney disease (CKD) and associated clinical outcomes, including inflammation, anemia, and bone/mineral...
- This federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $349,325 award to Regennova, Inc. aims to develop an orally-available, effective, and well-tolerated drug to treat autosomal dominant polycystic kidney disease (ADPKD). The overarching goal is to inhibit the arginine-polyamine pathway, which plays an important role in ADPKD,...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $128,286 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Broad Institute, Inc. in Cambridge, MA. The objective of this 2-year, 6-month project is to investigate the cellular mechanisms of lipid-induced toxicity (lipotoxicity) in kidney tubular epithelial cells and its contribution to the development of chronic kidney disease (CKD). The project...
This Project Grant award, totaling $859,980, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to develop novel adeno-associated virus (AAV) vectors capable of effectively targeting and delivering gene therapies to the kidney, with the goal of treating chronic kidney disease (CKD) and rare genetic kidney disorders like cystinuria. The research, conducted by the Vanderbilt University Medical Center, focuses on optimizing AAV capsids to improve kidney tropism and reduce liver sequestration, thereby enhancing the therapeutic potential and safety of gene therapies for the kidney. The project will evaluate the new AAV variants in mouse models and human kidney organoids to validate their efficacy in phenotypically correcting cystinuria. This award represents a significant effort to advance the field of kidney-targeted gene therapy and address the unmet need for effective treatments for devastating kidney diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $860.0k | 8/21/25 |