Project Grant R01DK142999
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Miami $537,250 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the neuronal entero-pancreatic circuit's role in glucose metabolism and insulin secretion. The recipient will uncover mechanisms coupling gut sensing to entero-pancreatic neurons, elucidate neurotransmitter pathways transmitting signals from the gut lumen to...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Miami $2,962,847 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to dissect the cellular dynamics and mechanisms of human pancreatic beta-cell regeneration using a novel in vivo model. The recipient will leverage an innovative transplantation system in which human pancreatic tissue slices and progenitor cells are engrafted into the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Florida $754,682 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate beta cell dysfunction in type 1 diabetes through glucose metabolism studies in human pancreatic tissue. The research addresses mechanisms of beta cell failure by examining glucose sensing and insulin secretory pathway components altered during type 1 diabetes...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $248,975 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, on May 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is a Project Grant. The research investigates pancreatic beta-cell dysfunction triggered by chronic high glucose, with focus on mRNA translation defects and their role in type 1 diabetes...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Regents of the University of Michigan $785,969 on February 6, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate secretory pathway protein degradation mechanisms that maintain insulin biogenesis and secretion in pancreatic beta cells. The award funds research into how pancreatic beta cells maintain approximately one billion insulin molecules per cell...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Virginia $782,459 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the impact of obesity on microvascular insulin action and cardiorespiratory fitness in individuals with Type 1 Diabetes. The research will test the hypothesis that endothelial oxidative stress and microvascular insulin resistance lead to reduced skeletal and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $248,322 to Adventhealth Orlando on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to determine cell- and spatially-distinct skeletal muscle transcriptional aberrations in insulin resistance and Type 2 Diabetes. The recipient will conduct research identifying transcriptional dysregulation in skeletal muscle across different cell types—myofibers, endothelial...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Florida $735,969 on August 10, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and test microgels for localized immune control in beta cell replacement therapy for type 1 diabetes. The work combines cell and biomaterials engineering to create stem cell-derived beta cells functionalized with negative regulators of immunity—specifically...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of The City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate how the native pancreatic microenvironment regulates human islet cell function in health and type 1 diabetes. The research employs human pancreatic tissue slices to preserve native cellular architecture and directly compares hormone...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $123,000 on June 16, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize adipocyte heterogeneity and response to metabolic stress. The funded research uses single-nucleus RNA sequencing and a humanized mouse model to investigate how diverse stimuli influence white adipocyte development and specification, with emphasis on...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Miami $534,988 on August 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the direct effects of physical exercise on pancreatic beta-cell function and mass. The project will employ high-resolution microscopy, single-cell transcriptional and epigenetic profiling, living tissue physiological assessment, and human islet transplantation models to define how exercise promotes beta-cell proliferation, survival, glucose sensing, and insulin secretion. Research will test the hypothesis that exercise activates transcriptional pathways involved in cell survival, enhances vascular function and resilience to metabolic stress, and optimizes islet transplantation outcomes. Work is performed in Miami, Florida and runs through June 30, 2031. The award is classified as a Project Grant, an assistance type supporting basic and clinical research that improves understanding of disease mechanisms and leads to improved prevention, diagnosis, and treatment of diabetes and related metabolic disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $535.0k | 8/7/26 |