Project Grant R01DK142982
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Texas Woman's University $133,175 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of DHRS9 in diet-induced obesity and diabetes. The research project will define how DHRS9 modulates insulin sensitivity under high-fat diet conditions across sexes and determine whether retinoid or specialized pro-resolving mediator (SPM)...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $295,649 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate adipocyte FGF1 signaling in systemic metabolism. The research examines fibroblast growth factor 1 (FGF1) as a potential lipid-lowering therapeutic target for hyperlipidemia and related metabolic disorders. Preliminary studies...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $694,250 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to explore a novel pathway for ApoB mRNA degradation in regulating VLDL secretion and steatotic liver disease. The recipient will conduct basic biomedical research identifying mechanisms by which the HELZ2 gene regulates hepatic lipid secretion...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $123,000 on June 16, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to characterize adipocyte heterogeneity and response to metabolic stress. The funded research uses single-nucleus RNA sequencing and a humanized mouse model to investigate how diverse stimuli influence white adipocyte development and specification, with emphasis on...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $710,470 to The University of Texas Southwestern Medical Center on August 1, 2026, for investigator-initiated biomedical research into prohormone convertase maturation and regulation under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funded research will characterize the structural basis for prohormone convertase 1/3 (PC1/3) activation; reveal how binding partners...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $639,990 to The University of Texas Health Science Center at San Antonio on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK144299). The recipient will investigate the role of oxidized phospholipids (OXPLs) in driving metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma (HCC). Research...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas at San Antonio $221,252 on September 12, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop a drug delivery system that modulates adipose tissue function. The project creates a locally injected adipose tissue nano-reservoir for continuous delivery of forskolin, a cyclic adenosine monophosphate activator that stimulates fat...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Chicago $6.511 million on September 20, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate macrophage roles in weight loss-induced metabolic health and adipose tissue inflammation resolution. The research examines how caloric restriction promotes a pro-resolving macrophage phenotype (termed CR-macrophages) that accumulates in visceral and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Maryland Baltimore County $249,000 on July 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of macrophage-derived transglutaminases in adipose tissue health and inflammation during obesity. The research will examine how transglutaminases—enzymes involved in extracellular matrix remodeling and immune regulation—drive...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $1.634 million on September 17, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to decode the neural mechanisms underlying bariatric surgery outcomes through activity and transcriptional analysis of melanocortin neurons. The recipient will employ electrophysiological techniques to study alterations in neuronal...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $813,299 on August 24, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic biomedical research on the regulation of obesity-related inflammation by alpha-melanocyte-stimulating hormone (α-MSH). The research investigates the role of α-MSH in coordinating immune and metabolic responses to inflammatory stress. Using newly developed mouse models with targeted α-MSH deletion, the recipient will determine the mechanism by which α-MSH deficiency exaggerates inflammation, define the central versus peripheral effects of α-MSH during immune challenge, and delineate the precise neuronal populations involved in regulating inflammation by α-MSH. The studies aim to provide evidence for melanocortin agonists as a therapeutic option for obesity-related inflammation and metabolic dysfunction-associated conditions including type 2 diabetes, atherosclerosis, and steatohepatitis. Work is performed in Dallas, Texas. The project runs from August 24, 2026, through May 31, 2031. This is a Project Grant, an assistance type supporting investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $813.3k | 8/24/26 |