This federal Project Grant award, valued at $715,501.00 and running from March 15, 2025 to January 31, 2030, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by The Trustees of Columbia University in the City of New York, conducted through the Health Sciences Division, to investigate the role of T helper cells and stem cells in colon homeostasis and tumor initiation. The key objectives are to: 1) determine if T cell cytokines modulate function of FGFBP1+ colon stem cells during epithelial regeneration; 2) examine if FGFBP1+ colon stem cells are cells-of-origin for neoplasia via conventional mutational pathways, and if T cell cytokines influence tumor initiation and progression; and 3) evaluate if FGFBP1+ colon stem cells function as cells-of-origin for neoplasia via non-conventional serrated pathways, and the role of T cell cytokines. This research aims to provide new insights into immune system interactions with epithelial stem cells during early tumorigenesis, with potential implications for prevention, diagnostics, and therapeutics.
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