Project Grant R01DK141981
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $235,403 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Johns Hopkins University. The funding will support the development of a membrane-reconstituted ZNT8 biosensor to detect cell-surface ZNT8 autoantibodies in the peripheral blood of patients with type-1 diabetes. This novel bioanalytical tool aims to enable the early detection of islet...
- This $2,782,476 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research to determine the molecular mechanisms underlying pancreatic beta cell response to metabolic stress, a key factor in the development of type 2 diabetes. The 4-year project aims to leverage in vitro human beta cell models, single-cell transcriptomic analyses, and targeted drug screening to delineate the dynamic chromatin and transcriptomic changes that...
- This $146,829 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the molecular mechanisms by which the bacterial protein BEFA (beta-cell expansion factor A) induces the proliferation and metabolic maturation of pancreatic beta cells. The research, conducted at the University of Oregon, utilizes single-cell imaging, genetic...
- This federal Project Grant award of $444,867.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research will use a novel mouse model to elucidate the pathological role of XBP1s in beta cell integrity under metabolic stress, in order to...
- This $847,746 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research by the Beckman Research Institute of the City of Hope to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research aims to identify the "tilting point" of the unfolded protein response (UPR) under metabolic stress and explore its potential for therapeutic interventions for...
- The University of California, Davis received a $126,480 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on the role of the signaling protein 14-3-3-z in regulating the crosstalk between pancreatic islet cells. The research aims to define a new pathway regulating 14-3-3-z expression in beta cells and investigate how this impacts alpha cell function and glucose-stimulated insulin secretion. This project is expected...
- This federal Project Grant award, in the amount of $531,999.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award is supporting research focused on understanding the role of alternative splicing in the proximal tubules of the kidney and its relationship to the progression of diabetic kidney disease. The research will investigate how diabetes...
- This federal Project Grant award of $803,748 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding research to investigate the modulation of insulin signaling in adipocytes (fat cells) and how improved adipocyte insulin sensitivity can contribute to positive metabolic outcomes. The research team at The University of Texas Southwestern Medical...
- This Project Grant award of $1,041,906.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Regents of the University of Michigan supports research investigating the role and mechanism of the UNC119B protein in the regulation of glucose homeostasis. The research aims to: Investigate the importance of UNC119B in each glucose-storing tissue for the maintenance of glucose homeostasis....
- This $532,177 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), supports research to investigate a novel inflammatory pathway in diabetic kidney disease (DKD). The research aims to elucidate the role of the transcription modulator I-MFA in regulating inflammatory cytokine production by glomerular mesangial cells, a key contributor to DKD pathogenesis. The 4-year project at the University of North Texas Health Science Center will...
This $1,405,949 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to characterize the novel transporter activity of the ZNT8 protein in islet beta cells and identify its endogenous substrates/metabolites. The goal is to gain mechanistic insights into the physiological roles of ZNT8 in islet biology and diabetes, with the potential to inform new therapeutic strategies for maintaining or restoring beta cell function and preventing beta cell loss. The award was granted to the University of Texas Southwestern Medical Center, a prominent academic medical research institution, and the project is scheduled for completion by August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 9/3/25 |