This is a $400,000 project grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of the project is to understand the earliest events in podocyte injury caused by mutations in collagen IV, which can lead to chronic kidney disease and end-stage renal failure. The research will use transcriptomic data from mouse models and human patient samples to identify...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Regents of the University of California, San Francisco (UCSF). The $246,000 award, effective August 19, 2024 through June 30, 2026, will support the development of novel genetic tools for studying type IV collagens. The goal is to create mouse models that enable visualization and biochemical...
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
This $142,902 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to uncover the mechanism by which the regulatory GTPase ARL13B drives polycystic kidney disease (PKD) pathogenesis. The research, led by Dr. Van Sciver at Emory University, will biochemically and genetically dissect ARL13B's interaction with three effector proteins - CDK1, ARL3,...
This $166,643 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports the development of robust phenotyping pipelines for early detection of collagen type IV-associated nephropathy (COL4A-AN) using electronic health records (EHR) data. The primary goal is to establish scalable phenotyping methods that leverage natural language processing (NLP) and...
This federal Project Grant award of $2,029,830.00, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the structures and channel properties of various polycystin protein complexes. The goal is to clarify the mechanistic roles of these disease-associated proteins, understand the impact of disease-associated mutations, and inform future...
This $176,244 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports a 5-year research project led by Dr. Gabriel Loeb at the University of California, San Francisco (UCSF). The project aims to study the regulation and function of the GLIS3 transcription factor, which is involved in primary ciliary signaling pathways related to polycystic...
This Project Grant award in the amount of $2,202,378.00 was awarded on September 20, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to investigate the protective role of the transcription factor KLF2 in diabetic kidney disease (DKD) and its potential as a drug target. The key objectives are to determine how KLF2 is regulated in diabetic...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $725,420 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop an optimized allysine-targeted positron emission tomography (PET) probe and validate it in animal models and human renal biopsy samples. The goal is to establish a non-invasive...