This Project Grant award of $571,980 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research supports research by Vanderbilt University Medical Center (VUMC) to investigate the role of the glutathione peroxidase 3 (GPX3) protein in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment - key pathological features of eosinophilic esophagitis (EoE). The 5-year project seeks to elucidate the mechanisms by which GPX3 influences these processes critical to EoE pathogenesis, with the goal of uncovering potential therapeutic strategies for this condition. The award leverages VUMC's clinical expertise and biomedical research capabilities to advance the scientific understanding of EoE.