This federal Project Grant award of $637,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to explore the production and signaling properties of novel bile acids produced by the gut microbiome. The project aims to 1) define the microbiology of microbially conjugated bile acid (MCBA) production, 2) determine the agonist activity of MCBAs on the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding how microbially-derived metabolites regulate host gut inflammation. The project aims to determine the regulatory role of these microbial metabolites on the host immune system, particularly through their...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the epigenetic regulation of intestinal tuft cells and their response to microbial signals. The $1,882,623 award to Childrens Hospital Medical Center in Cincinnati, OH will fund research to (1) determine how commensal bacterial metabolites instruct intestinal stem cell...
This Project Grant award, totaling $233,600.00 and spanning September 1, 2024 to June 30, 2027, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD), a debilitating condition characterized by chronic inflammation and erosion of intestinal functions. The...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,363,668.00 over 4 years to investigate how gut bacteria adapt to high-fat diets and the consequences for host metabolic health. The research will use evolved gut microbial communities from genetically distinct mouse lines to: 1) identify genomic signatures of bacterial...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $533,907.00 to Rutgers, The State University to investigate the role of the epigenetic regulator TET3 in protecting intestinal epithelial cells against inflammatory stressors. The project aims to decipher the mechanisms by which TET3-mediated DNA oxidation and transcriptional...
This $206,615 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at Duke University to investigate the genetic mechanisms that enable the gut bacterium Phocaeicola vulgatus to effectively colonize the mammalian gut environment. The research aims to define the specific genes and molecular functions within a Phocaeicola-specific operon that confer competitive...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $516,648.00 to investigate the role of epigenetic memory in intestinal regeneration. The research aims to characterize how inflammatory exposure alters the epigenetic landscapes of intestinal stem cells and impacts their regenerative capacity. Key objectives include perturbing...
This Project Grant award, totaling $216,736.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research project aims to identify the mechanisms by which the host circadian clock and gut microbiome regulate mucus production in the large intestine to protect against infectious and chemical colitis. Key objectives include determining the specific microbiota...