The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $348,657 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Hennepin Healthcare Research Institute (HHRI) to develop a clinical decision support tool to help nephrologists evaluate kidney transplant candidates with a history of cancer. The project aims to:
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Estimate mortality risk for kidney transplant candidates with a history of cancer, comparing those who are transplanted vs. not yet transplanted, using data from the Transplant Cancer Match (TCM) study.
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Estimate mortality risk for end-stage kidney disease patients with a history of cancer who are not yet listed for transplant, compared to transplanted TCM study patients, through a novel linkage between the United States Renal Data System (USRDS) and cancer registries.
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Develop a free, user-friendly online tool for nephrologists to use the mortality estimates from the first two aims to guide transplant waitlisting decisions for candidates with a history of cancer.
The award period runs from September 5, 2024 to July 31, 2029, and the project aims to address the critical need to better serve kidney disease patients with a history of cancer by improving predictions of pre- and post-transplant outcomes.
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