Project Grant R01DK140239

This federal Project Grant award of $737,034.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this 5-year research project, with a start date of September 1, 2025, is to identify new regulatory inputs that control the biosynthesis of coenzyme A (CoA) in response to the metabolic state of cells and tissues, especially the kidney and liver. The research will leverage unique advantages of fly and mouse models, mass spectrometry-based metabolomics and lipidomics, metabolic flux analyses, and protein biochemistry to advance the understanding of how insulin regulates cellular metabolism and reveal new regulatory mechanisms for CoA synthesis. Successful completion of this project is expected to provide important insights into the pathological dysregulation of lipid metabolism observed in metabolic diseases like non-alcoholic fatty liver disease and chronic kidney disease.