This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA Program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, will support a $641,873 research study by Wake Forest University Health Sciences (WFUHS) over 4 years starting September 1, 2024. The study aims to analyze genetic and molecular factors in kidneys from deceased African American donors that may impact transplant outcomes, with the goal of developing a rapid testing panel to optimize kidney allocation from donors with high-risk genetic variants. Key work includes assessing correlations between apolipoprotein L1 (APOL1) protein levels in donor kidneys and transplant outcomes, as well as performing transcriptomic analyses to identify other genetic components that may interact with APOL1 to influence transplant success. This research could lead to improvements in kidney transplant survival rates and increased utilization of high-quality kidneys from African American donors, addressing a critical need for patients with end-stage kidney disease.
Generated 2/25/25, 4:41 AM