This Project Grant award of $497,370 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the CD45 phosphatase in regulating neutrophil function and inflammatory responses during intestinal inflammation. The research, to be conducted by the Regents of the University of Michigan, aims to determine the effects of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) provides $637,000.00 to Michigan State University from August 1, 2024 through May 31, 2029. The award will fund research to investigate how "microbially conjugated bile acids" (MCBAs) produced by the gut microbiome can alter gut inflammation and disease outcomes. The project will: 1) Define the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $216,736 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of the University of Pennsylvania. The goal of this project is to identify how the host circadian clock and gut microbiome regulate mucus production in the large intestine through a newly identified gene. The research aims to characterize the specific microbial and temporal...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Michigan a Project Grant totaling $108,000 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Michigan Summer Undergraduate Research Experience: Diabetes & Metabolic Diseases", will support a 5-year program to provide 14 undergraduate students per year with a meaningful summer research experience and mentorship to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on understanding how microbially-derived metabolites regulate host gut inflammation. The $364,324 award, with a performance period from August 2024 to February 2027, will enable research to characterize the regulatory role of these metabolites on the host immune system, particularly...
This $1,355,273 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of Michigan. The grant funds the development of two complementary approaches to inhibit the production of the bacterial metabolite colibactin, which has been linked to colorectal cancer and microbiome dysbiosis. The first approach involves enzymatic inactivation of colibactin through...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $584,214 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The grant funds the development of a solid-state fermentation platform to manufacture defined live microbial therapeutic products (LBPs) on an accelerated timeline. This will enable the generation of multiple LBP drug candidates to treat recurrent...
This federal Project Grant award, with a total funding amount of $241,130.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, effective August 16, 2024, with a final completion date of March 31, 2027, supports research on "ADAPTIVE RESPONSE(S) TO COMPLETE THYROGLOBULIN GENE KNOCKOUT" to be conducted by the Regents of the University of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $148,568.00 to support research aimed at elucidating the mechanisms of Notch signaling in intestinal stem cells. The key objectives of the research are to: 1) define the Notch niche for intestinal stem cells throughout development; and 2) investigate whether intestinal stem...
This federal Project Grant award of $664,163 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research" will support research to investigate the role of CD39 expression in gamma delta intraepithelial lymphocytes (GD IELs) and its impact on immune function and metabolic regulation in inflammatory bowel disease (IBD). The research aims to elucidate the mechanisms by which CD39...