Federal Grant Award Summary

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Washington University a Project Grant totaling $537,032 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 1, 2026, through March 31, 2031. This research project investigates the role of protein S-palmitoylation in beta cell dysfunction associated with type 2 diabetes (T2D). The research will examine how acyl-protein thioesterase 1 (APT1) and its substrate SCAMP1 (secretory carrier membrane protein 1) regulate insulin secretion and beta cell survival through reversible palmitoylation modifications. The project will test the hypothesis that depalmitoylation mechanisms affect beta cell function and glucose homeostasis, with potential implications for understanding and treating T2D complications.

Washington University's Office of Sponsored Research Services will deliver fundamental biomedical research services aimed at improving understanding of T2D disease mechanisms and identifying potential therapeutic targets. The research employs molecular and cellular biology approaches using both human islet cells and transgenic mouse models to characterize palmitoylation-dependent signaling pathways. Findings from this four-year initiative are expected to contribute to the broader NIH mission of advancing knowledge of diabetes pathogenesis and supporting the development of improved preventive and treatment strategies for this lethal disease and its associated complications.