This federal Project Grant award of $800,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to discover new signaling molecules called "mammokines" that may play critical roles in the communication between the mammary gland and other organs like the liver, pancreas, and adipose tissue. The research seeks to understand how the secretome of the mammary...
This federal Project Grant award, valued at $524,837, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to investigate the role of enteric glial mechanotransduction and the impact of mechanical stress on postoperative ileus and gastrointestinal dysfunction. Key products and services to be delivered include utilizing innovative...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $340,822 to the University of Pittsburgh to investigate the role of cell surface glycosaminoglycans in parathyroid hormone-related protein (PTHrP) signaling. The goal is to determine the molecular and cellular mechanisms by which heparan sulfate controls PTHrP signaling through...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund the establishment of the National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BIOPITNET). This $5.68M award, spanning 5 years, will create a centralized biorepository and resource to advance research on pituitary neuroendocrine tumors...
This $288,980 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research to investigate the mechanisms of beta and delta cell coordination within pancreatic islets under high glucose conditions. The award to the University of California, Davis aims to definitively establish the predominant mechanisms, whether paracrine signaling...
This $1,558,188 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate how changes in transcription factor and heterochromatin states impact liver development, homeostasis, and regeneration. The primary awardee, The Trustees of the University of Pennsylvania, will use advanced in vivo imaging technologies and genetic...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Appalachian State University a $504,705 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Examining Estrogenic Regulation of Orexin Neurons to Reveal Subpopulations," will support research examining the role of orexin neurons in sleep, energy balance, stress, motivation, and reward. The project aims to better understand how...
This federal Project Grant award of $1,540,684 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to understand the cellular mechanisms driving heterogeneous bone marrow stress responses across different skeletal sites. Specifically, the research will investigate how bone marrow macrophages control the differential response to G-CSF in the sternum...
This federal Project Grant award of $105,398.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to assess the persistent effects of dietary protein restriction on protein motivation and underlying physiology in animals. Specifically, the research will examine measures of protein preference, economic "demand", FGF21 production, and...
This federal Project Grant award in the amount of $1,428,186 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, and the impact of this biochemical interaction on cellular metabolism and downstream biomarkers of cardiometabolic disease. The...