Project Grant R01DK139157
- This federal Project Grant award of $828,771 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to study the neural mechanisms underlying the metabolic benefits of bariatric surgeries, such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB). The key objectives are to employ electrophysiological techniques to analyze changes in neuronal excitability and...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $168,900 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. This grant, awarded on Jul 15, 2025, supports research to determine how the commensal bacterial species Blautia activates signaling events within the gut epithelium to benefit host metabolism and mucosal health....
- This $168,252 federal Project Grant awarded on September 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Trustees of Boston University (DBA Boston University Medical Campus) to study the molecular mechanisms of nuclear receptor corepressors NCOR1 and SMRT and their role in regulating metabolism via actions in the intestine. The overarching goal is to expand...
- This federal Project Grant award in the amount of $1,428,186.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts. The project aims to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, which has implications for understanding the early...
- The University of Texas Health Science Center at San Antonio received a $775,865 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) on September 10, 2025. The award supports research to investigate the glycemic effects of glucagon in individuals with and without gastric bypass or sleeve gastrectomy surgery. The research aims to measure the impact of exogenous glucagon...
- The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...
- This Project Grant award of $325,408 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports the development of an easy-to-operate endoscopic automatic gastroplasty device that mimics the effect of gastric bypass/bariatric surgery. The device is intended to provide a minimally invasive, non-surgical weight loss solution for the treatment of diabetes and obesity. The technology creates a reinforced circular plication of stomach tissue to reduce the stomach...
- This federal Project Grant award of $802,843, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Yale University to investigate the relationship between intestinal microbial activity and human metabolism. The key objectives are to: 1) understand how insulin resistance affects the adipose tissue lipolysis response to intestinal...
- This federal Project Grant award for $836,942 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research into the role of autophagy (self-digestion) in intestinal regeneration and stem cell activity. The research aims to investigate how autophagy contributes to injury resistance and the ability of certain intestinal cell types to re-acquire stem cell-like...
- This $2,559,138 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the mechanisms regulating adipose (fat) tissue metabolic memory and its role in rebound weight gain following obesity treatment. The project, led by researchers at the University of Pennsylvania, aims to: 1) determine the role of LYVE1+ macrophages in...
This Project Grant award of $3,103,125 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the role of lipogenic pathways in intestinal remodeling after Roux-en-Y gastric bypass surgery. The central hypothesis is that alterations in intestinal epithelial lipid homeostasis, driven by LXR and PPARA signaling, are necessary for Roux limb adaptation and associated improvements in glucose homeostasis after bariatric surgery. The research aims to directly test the role of lipogenic pathways in contributing to intestinal adaptation and metabolic homeostasis. The award was made to The Children's Hospital Corporation, doing business as Boston Children's Hospital, and the project will be conducted in Massachusetts over the period from September 3, 2025 to September 2, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 9/3/25 |