The Regents of the University of Michigan was awarded a $484,027 Project Grant by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to investigate the role and mechanism of the protein UNC119B in regulating glucose homeostasis, with the goal of developing new treatments for type 2 diabetes. The key products or services to be delivered under this 4-year grant include: 1) Determining the importance of UNC119B in glucose storage tissues (skeletal muscle, adipose, heart) for maintaining glucose homeostasis; 2) Evaluating whether improved insulin sensitivity from UNC119B inhibition or deletion protects pancreatic beta cells from damage; and 3) Identifying the molecular mechanisms and protein interactions underlying UNC119B's regulation of glucose transporter 4 (GLUT4) translocation. The research seeks to establish UNC119B as a new component of the insulin signaling cascade and assess the therapeutic potential of targeting this protein for type 2 diabetes treatment.
Generated 2/25/25, 2:43 AM