This $352,618 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to investigate the role of the pancreas microenvironment in regulating islet function and survival in type 1 diabetes. The key objectives of this 5-year research project are to: 1) Determine if cytokine-stressed beta cells degrade the peri-islet extracellular matrix (ECM)...
This $561,893 Project Grant was awarded on September 19, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to systematically evaluate the molecular cascade involving Type 2 Diabetes (T2D) effector genes, the regulatory factors RFX3 and RFX6, and T2D-associated genetic variants in human islet cell generation, survival, and function. The research will...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to define the molecular determinants of inflammatory memory in the pancreas. The $506,546 award, with a performance period from July 1, 2024 to May 31, 2029, will be performed by the Weill Medical College of Cornell University. The research aims to leverage...
This $530,890 Project Grant award was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to identify tissue- and disease-specific processes that underlie type 1 diabetes (T1D) susceptibility by comparing autoimmune T cell development and function in mouse models expressing T1D-associated major histocompatibility complex class II (MHC-II) alleles...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $125,162 to the University of Florida to measure changes in central carbon and lipid metabolism in the exocrine pancreas of a mouse model of type 1 diabetes. The research will utilize novel pancreas perfusion methods combined with nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to investigate the role of the signaling protein 14-3-3z in regulating islet function and the crosstalk between pancreatic alpha and beta cells. Specifically, the $399,545 award to the University of California, Davis will test the hypothesis that inhibition of 14-3-3z in beta...
The federal Project Grant award R56DK140109 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $444,867 award, with a period of performance from Sep 1, 2024 to Aug 31, 2025, supports research conducted by the Beckman Research Institute of the City of Hope to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under...
This $437,156 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to investigate the mechanisms underlying the impaired insulin release that leads to cystic fibrosis-related diabetes (CFRD). The research will be conducted by the University of Alberta in Canada and will utilize primary human cells, including pancreatic ductal...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $205,280 to investigate the mechanisms of coordination between pancreatic beta and delta cells in response to high glucose levels. The project will focus on understanding the role of gap junction coupling and paracrine signaling in regulating the synchronized activity of these...
This $1,338,684 federal Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA Program 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a longitudinal study to assess insulin vesicle functional capacity, beta cell mass, and pancreas volume in individuals at risk for and with recent onset type 1 diabetes. The study aims to utilize PET and MRI techniques to provide a comprehensive picture of beta cell...