This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $692,243 to Yale University to conduct research on the role of lymphatic vessels in cholestatic liver diseases. The goal is to explore the potential of increasing lymphatic vessels as a therapeutic option and understand the underlying molecular mechanisms driving lymphangiogenesis (formation of new lymphatic vessels) in the context of cholestatic liver injury. The research will focus on determining the beneficial effects of the hepatic lymphatic system, elucidating how bile acids impact lymphatic endothelial cell functions, and evaluating the spatial and temporal regulation of lymphatic vessels and their impact on the progression of cholestatic liver disease. The award period runs from September 1, 2024 to June 30, 2028.
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