The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $665,717 Project Grant under its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA. The award will fund a 4-year research project to biochemically characterize N-acyl amino acids as substrates and competitive inhibitors of CYP4F enzymes, define the functional consequences of N-acyl amino acid inactivation by CYP4F hydroxylation on cellular metabolism, and identify novel N-acyl amino acid downstream products as biomarkers for cardiometabolic disease. This research aims to establish the biochemical basis for the association between the CYP4F gene locus and N-acyl amino acids in humans, ultimately providing insights into therapeutic strategies for obesity and type 2 diabetes.
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