This Project Grant award of $294,641 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting the development of a low-cost ultrasound imaging system that can be operated by untrained users. The small business awardee, Sonovance, Inc., is working to optimize and validate their patented system for guiding unskilled operators to obtain acceptable diagnostic...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), funded under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a noninvasive method for earlier detection of skeletal muscle insulin resistance and dysfunction as a precursor to type 2 diabetes. The $389,621 award will support prospective ultrasound imaging of skeletal muscles, concurrent laboratory testing, and analysis of muscle...
This $548,830 Project Grant awarded on August 1, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop and test a point-of-care device to predict the future development of severe acute kidney injury (AKI). The grantee, Nephsmart LLC, will leverage their discovery that extensive cleavage of a specific protein occurs in the urine of patients with mild AKI...
The federal Project Grant award K23DK138292, totaling $184,572.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to characterize the transmural nature of ulcerative colitis and its associated disease-related outcomes using intestinal ultrasound. The goal is to identify new therapeutic targets and endpoints for clinical trials...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This federal Project Grant award of $593,241.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA Program 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research - aims to improve proteinuria testing and management after acute kidney injury (AKI). The principal investigator, Dr. Y. Diana Kwong, a nephrologist at the University of California, San Francisco (UCSF), will conduct qualitative interviews, retrospective and prospective analyses...
This federal Project Grant award for $153,540 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at Columbia University to perform human genome-wide association studies (GWAS) to identify genetic risk variants associated with urinary tract infections (UTIs). The research aims to discover novel genes and cell types involved in immune...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research focused on understanding the molecular and genetic mechanisms underlying ischemic acute kidney injury (AKI). The $117,000 award, with a performance period from August 2024 to July 2026, will investigate the hypothesis that the transcription factor PAX8 controls sensitivity to...
This Project Grant award of $214,958 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of Interferon-Stimulated Gene 15 (ISG15) as a regulator of cell death pathways during acute kidney injury (AKI). The research, led by investigators at The Washington University in St. Louis, aims to advance the understanding of the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $576,296 Project Grant to the University of California, Los Angeles (UCLA) to conduct research on the mechanisms by which iron deficiency can exacerbate inflammatory tissue injury. The research aims to define how iron deficiency potentiates inflammation, worsens inflammatory lung and kidney injury, and modifies...