The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $627,541 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Childrens Hospital Medical Center in Cincinnati, Ohio. The grant supports research to investigate how the intestinal microbiota and associated metabolites epigenetically regulate the development and function of intestinal tuft cells, which play a key role in sensing microbial signals and modulating intestinal immunity. The research aims to uncover novel epigenetic mechanisms that connect the microbiome to tuft cell biology, with the goal of guiding personalized approaches for treating intestinal diseases. The project will run from August 1, 2024 through June 30, 2028.
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