This federal Project Grant award of $796,293 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to establish pathogenic autoimmunity and identify the direct effects of anti-nephrin autoantibodies on podocyte structure and function in minimal change disease and focal segmental glomerulosclerosis. The primary awardee, Brigham & Women's Hospital, will collaborate with researchers at the University of Michigan, Nationwide Children's Hospital, and Boston Children's Hospital to analyze transcriptomic data, assess cellular signatures, and conduct genomic sequencing on patient samples to elucidate the underlying pathomechanisms of this autoimmune-mediated diffuse podocytopathy. This research seeks to provide critical insights for developing novel, personalized treatment strategies for patients suffering from these kidney disorders, including those with recurrent disease after transplantation.
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