This $598,940 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to characterize the longitudinal events of oral high-risk human papillomavirus (OHR-HPV) infection among an at-risk population of non-heterosexual males living with or without HIV in Nigeria. The primary objectives are to: 1) determine the association between HIV clinical markers, oral-anogenital contact, and the prevalence of OHR-HPV; 2) compare the time course of OHR-HPV as a function of HIV status; and 3) evaluate the relationship between dental phenotypes, the oral microbiome, HIV clinical measures, and OHR-HPV infection. The project will leverage an established cohort at the Trust Clinic in Nigeria and follow 500 participants over 2 years, collecting oral, blood, and clinical data to better understand the natural history of OHR-HPV and its link to HIV, the oral microbiome, and oral health indicators. This research aims to inform predictive models and risk-stratified screening approaches to mitigate the risk of HPV-related oropharyngeal cancer in males living with HIV. The University of Maryland, Baltimore is the prime awardee, with sub-awards to the Institute of Human Virology Nigeria and the University of Pennsylvania to support the study's implementation in Nigeria and provision of specialized research services, respectively.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $598.9k | 8/20/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
22016KB7171S | Institute Of Human Virology NIG Ltdgte | Project Grant R01DE033862 | $105.9k | 11/25/24 | |
21998KB7261S | The Trustees Of The University Of Pennsylvania | Project Grant R01DE033862 | $52.3k | 10/31/24 |