The University of Southern California (USC) Department of Contracts and Grants Division is the recipient of a $589,725 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The objective of this 5-year research project is to use multi-modal single-cell and imaging technologies to establish a comprehensive molecular, cellular, and innervation map of the temporomandibular joint (TMJ) under healthy and osteoarthritis (OA) conditions in mouse models. The research aims to unveil the underlying mechanisms of TMJ degeneration and pain, and to validate Netrin-1/DCC as potential therapeutic targets for mitigating TMJ OA pain. The project leverages the collaborative expertise of USC investigators in neuroscience, craniofacial biology, and skeletal pain to deliver this innovative and interdisciplinary research.
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