Project Grant R01DC022483
- This federal Project Grant award for $486,750.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program. The grant supports research to explore the morphological changes and cell polarity mechanisms in supporting cells of the inner ear, which play a critical role in auditory function. The primary awardee, the Jackson Laboratory, a nonprofit biomedical research...
- This federal Project Grant award of $781,703, awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders", supports research to better understand sensory development in human cochlear organoids. The goals are to define the developmental trajectories of key sensory cell types, test methods to increase the number of hair cells, and accelerate the maturation of hair cells and sensory...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, will fund the development of a CRISPR-based toolkit to investigate hair cell transcription factors in inner ear organoids. The $249,000 grant awarded to Merrimack College will enable the research team to: 1) Define the transcription factors involved in in vitro inner ear organoid hair cell development...
- This $647,518 Project Grant award, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, supports research investigating the impact of cochlear synaptopathy on brainstem mechanisms of monaural temporal processing and binaural hearing. The study aims to understand the neural mechanisms and loci in the auditory system that produce listening difficulties, which can emerge...
- The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $410,534 Project Grant to The Medical University of South Carolina (MUSC) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant, awarded on September 10, 2025, seeks to identify genetic modifiers that influence the penetrance of hearing impairment in the context of Endothelin receptor EDNRB deficiency. The research aims to address the role of the KCNJ16 gene, which...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $767,494 to the University of Miami to develop human inner ear organoid platforms for studying genetic hearing loss and vestibular disorders. The key objectives are to: 1) establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with...
- This $115,158 Project Grant, awarded on February 1, 2025 by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research into the neurological mechanisms underlying hearing loss. The central hypothesis is that the presentation of phosphatidylserine acts as a signal to mark inactive spiral ganglion neuron connections with outer hair cells for removal, facilitating...
- The National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded a $589,393 Project Grant to Northwestern University to support research on the development of cochlear innervation. The goal is to elucidate how the neural circuit in the mammalian cochlea assembles during development, by altering the identity of certain cell types involved. Through this project, the researchers will...
- This Project Grant award of $670,318, provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 - Research Related to Deafness and Communication Disorders, will fund research to investigate the biological functions of the CHD7 gene and its role in the inner ear development pathology of CHARGE syndrome. The key objectives are to: 1) Establish human embryonic stem cell lines with specific CHD7 mutations to study their impact on gene/protein...
- This Project Grant award of $637,500.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173). The goal of the project is to understand the forward transduction that drives inner and outer hair cell stereocilia, as well as the reverse transduction that amplifies motion in the human cochlea, using a novel finite element modeling technique. The research will focus...
This Project Grant award, titled "Epigenetic Mechanisms of Cochlear Damage and Repair," was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders (CFDA 93.173) federal grant program. The $652,216 award to Rutgers, The State University will support research to investigate the role of the CHD4 protein in maintaining hair cell identity and function in the cochlea. The 5-year project aims to examine how CHD4 ablation leads to hair cell degeneration and changes in supporting cell epigenetics, with the goal of providing mechanistic insights into hair cell maintenance and regeneration that could inform new treatments for hearing loss. This award falls under the NIDCD's broader mission of supporting scientific research to understand and address challenges related to communication disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $652.2k | 8/20/25 |