Project Grant R01DC021970
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA program "Research Related to Deafness and Communication Disorders" (93.173), provides $693,856 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the structure and function of coordinated neural activity in the auditory system. The key objectives of this 5-year research project are to: 1) Identify coordinated neural...
- This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $195,180 to the University of Pittsburgh to investigate the modulation of layer 5 neurons in the auditory cortex by arousal state. The project aims to characterize how different types of layer 5 neurons in the auditory cortex respond to changes in arousal state using in vivo...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to investigate vocal dysfunction and vagally mediated brainstem pathology in the prodromal stage of Parkinson's disease. The $126,442 award to the University of Wisconsin - Madison will fund a study using a rat model with a PINK1 gene knockout to evaluate differences in vocal,...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $816,063 to The Trustees of Columbia University in the City of New York to conduct research on the neural mechanisms underlying how social stimuli elicit motivated behavior. The key focus of the research is to understand how neural representations of social rank information, such as dominant and submissive social cues, converge onto brain...
- This $631,703 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) aims to investigate the use of muscle progenitor (stem) cells for treating vocal fold paralysis. The research project, conducted by The Washington University, will test the effectiveness of implanting these cells into the laryngeal muscles of canine models to improve nerve recovery...
- This Project Grant award from the National Science Foundation (NSF) Division of Behavioral and Cognitive Sciences supports research at the University of California, Irvine (UC Irvine) to investigate the neural mechanisms underlying speech production. The project aims to generate a functional map of the brain systems that enable fluent speech, with the goal of improving diagnosis and treatment of speech production deficits. The $965,471 award, effective August 1, 2023 through July 31, 2026,...
- This $380,376 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA program 93.173 "Research Related to Deafness and Communication Disorders" will support research at Brown University on the convergence of behavioral and sensory information in the olfactory cortex of mice. The key objectives are to: 1) Determine whether behavioral signals in the piriform cortex support predictive processing of odor information, and 2)...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $151,040 to the University of California, Los Angeles (UCLA) to conduct research on the neural mechanisms regulating affiliative social behaviors in mice. The key objectives of the project are to: 1) utilize optogenetics to manipulate oxytocin-responsive neurons in the medial amygdala and their projections to other brain regions involved in...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research to investigate the mechanisms underlying the olivocochlear system's ability to enhance cochlear function in mice. The $416,642 award, valid from July 2024 to June 2026, will enable researchers at the University of Rochester to: 1) isolate and systematically evaluate the...
- This $559,886 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.853) supports research by Oregon Health & Science University (OHSU) to investigate the molecular and neuronal basis for sexual dimorphism in a vocal-motor control circuitry. The research aims to define how hormonal and genetic factors modulate neurodevelopment, in order to better understand the origins of sex differences in brain function and behavior, address sex biases in...
THE BRAINSTEM VOCAL CONTROL CIRCUITS - ABSTRACT VOCALIZATION IS USED IN MANY SPECIES FOR SOCIAL AND EMOTIONAL COMMUNICATIONS. INTERESTINGLY, MICE CAN EMIT TWO TYPES OF VOCALIZATIONS: ULTRASONIC VOCALIZATIONS DURING SOCIAL AND COURTSHIP INTERACTIONS (USVS) AND AUDIBLE SQUEAKS IN RESPONSE TO STRESS AND PAIN. WHILE PREVIOUS STUDIES, INCLUDING OUR OWNS, HAVE UNCOVERED HIGHER CENTERS REGULATING VOCALIZATION, SUCH AS THE GATING OF USV PRODUCTION BY NEURONS IN THE PERIAQUEDUCTAL GRAY (PAG), THE PRECISE NEURONAL CELL TYPES AND THE MECHANISMS FOR PRODUCING THE ACTUAL SOUNDS VIA VOCAL CORD ADDUCTION AND VOCAL-BREATHING COORDINATION REMAIN POORLY UNDERSTOOD. THE CIRCUIT ELEMENTS THAT SELECTIVELY REQUIRED FOR ELICITING AUDIBLE SQUEAKS IN MICE ALSO REMAIN UNKNOWN. THE OBJECTIVE OF THIS RESEARCH PROPOSAL IS TO SOLVE THESE TWO FUNDAMENTAL QUESTIONS OF VOCAL CONTROL. IN PRELIMINARY STUDIES, WE HAVE USED ACTIVITY-DEPENDENT METHOD THAT IDENTIFIED EXCITATORY VOCAL PREMOTOR NEURONS LOCATED IN THE RETROAMBIGUUS NUCLEUS (RAMVOC) AS SUFFICIENT FOR DRIVING VOCAL-CORD CLOSURE AND ELICIT USVS. RAMVOC NEURONS ARE ALSO ABSOLUTELY NECESSARY FOR BOTH USVS AND SQUEAKS HERE, WE WILL (1) TRANSCRIPTOMICALLY DEFINE THE CELL TYPES OF ALL LARYNGEAL PREMOTOR (PRE-MNLARY) AND AS WELL AS ALL RAMVOC PRESYNAPTIC (PRE- RAMVOC) NEURONS; (2) DETERMINE THE ACTIVITY AND FUNCTION OF PREBOTCINH - RAMVOC PATHWAYS IN VOCAL- RESPIRATORY COUPLING; AND (3) DETERMINE THE ROLES OF DIFFERENT POPULATIONS OF PERIAQUEDUCTAL GRAY (PAG), KOLLIKER-FUSE (KF), NUCLEUS SOLITARY TRACT (NTS) NEURONS IN DRIVING AUDIBLE EMOTIONAL VOCALIZATIONS. WE EXPECT TO NOT ONLY IDENTIFY THE HITHERTO UNKNOWN CIRCUITS THAT TRIGGER EMOTIONAL CRIES BUT ALSO REVEAL PRECISE CELLS AND MECHANISMS UNDERLYING VOCAL-RESPIRATION COORDINATION AND LAY MOLECULAR FOUNDATIONS FOR FUTURE DISSECTION OF OTHER ASPECTS OF VOCAL CONTROL (PITCH AND SHAPE OF SYLLABLES), FOR FINDING POTENTIAL TREATMENT TARGETS FOR DYSPHONIA AND OTHER DISORDERS RELATED TO MOTOR SPEECH PRODUCTIONS, AS WELL AS FOR REVEALING HOW OTHER PHYSIOLOGICAL NEEDS CONTROL VOCAL CORD MOVEMENTS IN HEALTH AND DISEASES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $558.6k | 5/14/25 | ||
| Not listed | $573.3k | 7/17/24 | ||
| Not listed | $573.3k | 7/17/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
S6429S | Allen Institute | Project Grant R01DC021970 | $227.0k | 9/11/24 |