The Leland Stanford Junior University, also known as Stanford University, has been awarded a $690,773 Project Grant from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant, with an award date of December 15, 2024 and an ultimate completion date of November 30, 2029, will fund research to determine how the natural hair bundle stimulations shape the hair cell receptor current.
The research aims to understand how the mechano-electrical and electromechanical feedback between the hair bundle, its environment, and outer hair cell electromotility regulate the sensitivity and selectivity of the cochlear output. Key objectives include measuring hair bundle motion in situ, identifying the hair bundle and tectorial membrane components driving the hair bundle response, and assessing receptor current properties under physiologically relevant modes of stimulation. This foundational work is expected to provide insights into cochlear mechanics and inform the development of treatment strategies for genetic disorders and age-related hearing loss affecting the hair bundle.
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