Project Grant R01DA066132
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Miami's Office of Research Administration at the School of Medicine a $164,190 Project Grant on August 19, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The research project, titled "Dopamine Dysregulation and Oxidative Stress in HIV and Methamphetamine Induced Cognitive Impairment," addresses the overlapping public health epidemics of substance use disorder and...
- Summary Florida International University received a $14.7M Cooperative Agreement award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 30, 2025, through June 30, 2030. The award supports the continuation and expansion of the Miami Adult Studies on HIV (MASH) cohort, a longitudinal research initiative investigating the intersection of HIV, substance use (specifically cocaine), and associated comorbidities...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $804,728 to the Regents of the University of California at Riverside under the Drug Use and Addiction Research Programs (CFDA 93.279) to support a five-year research project spanning June 1, 2025 through April 30, 2030. This Project Grant will fund research investigating the interaction between methamphetamine use and human immunodeficiency virus (HIV) persistence, specifically examining the role of the...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $6.99 million to the University of California, San Francisco under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct an in vivo imaging and post-mortem research study examining the effects of methamphetamine (MA) use on immune dysfunction and HIV-1 reservoir transcription among people with HIV on antiretroviral therapy (ART). The project, initiated July 15, 2025, and extending through...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA), under its Drug Use and Addiction Research Programs (CFDA 93.279), awarded $109,652 to the University of Miami's Office of Research Administration on August 19, 2026, for an implementation research study examining telehealth delivery models for HIV and substance use disorder (SUD) care among people who inject drugs (PWID). This one-year project, scheduled for completion by August 18, 2027, will produce research...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded Johns Hopkins University a $668,423 Project Grant effective April 15, 2026, through March 31, 2028, under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research investigating MECOM (MDS1 and EVI1 Complex Locus Protein)-associated microglial mechanisms in HIV persistence and methamphetamine-induced neuroinflammation. Johns Hopkins will deliver integrated transcriptomic and proteomic...
- Federal Grant Award Summary The University of Miami received a $677,248 Project Grant award from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test the Comprehensive Telehealth Concierge (C-THR) model. The grant, awarded February 15, 2026, with a completion date of December 31, 2030, funds a randomized controlled trial designed to improve HIV Pre-Exposure Prophylaxis (PrEP) initiation and retention among individuals with...
- Grant Award Summary The University of Miami has been awarded $793,508 under the Drug Use and Addiction Research Programs (CFDA 93.279) administered by the National Institute on Drug Abuse to develop and deploy STRIVES (Status-Neutral Tele-Health Concierge Intervention for People Who Use Drugs via Engagement Through Street Medicine). The project, initiated on March 1, 2026, and extending through January 31, 2031, addresses the critical public health intersection of homelessness, substance use...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded University of Miami $677,250 under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 15, 2025, for development and testing of the Healthcare Empowerment and Advocacy for Recovery from Trafficking (HEART) intervention. The project, extending through May 31, 2028, addresses the intersecting public health emergencies of sex trafficking, opioid use disorder, and HIV epidemic by creating a peer-delivered brief...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Alabama at Birmingham a $2.23 million Project Grant on May 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the molecular mechanisms by which HIV and HIV proteins enhance amphetamine use disorder and psychostimulant abuse escalation. The research focuses on understanding the bidirectional relationship between HIV infection and amphetamine use disorder—termed a...
The University of Miami's Office of Research Administration has been awarded $516,914 under the Drug Use and Addiction Research Programs (CFDA 93.279) by the National Institute on Drug Abuse (NIDA) to conduct a five-year project grant effective May 1, 2026 through February 28, 2031. This research initiative investigates the molecular synergy between HIV (human immunodeficiency virus) infection in brain pericytes and methamphetamine use, with the goal of advancing understanding of central nervous system (CNS) HIV reservoirs and improving treatment approaches for HIV-associated neurological disorders. The project employs transdisciplinary experimental models utilizing primary human brain pericytes and brain microvessels isolated from people living with HIV with substance use disorder, evaluating methamphetamine's modulatory impact on innate immune dysregulation, mitochondrial dysfunction, epigenetic regulation of HIV latency, and estrogen receptor signaling. This research addresses a critical knowledge gap regarding how latent HIV infection forms and persists in previously unrecognized cellular reservoirs, particularly in the context of psychostimulant use. The deliverables encompass new scientific knowledge concerning the mechanisms underlying HIV latency maintenance in brain pericytes, novel insights into how methamphetamine influences these mechanisms, and evidence-based findings applicable to developing an HIV cure and effective treatment of HIV-associated neurological complications in individuals with substance use disorders. The work is conducted at the awardee's facility in Miami, Florida, and contributes to NIDA's broader portfolio supporting basic, translational, and clinical research in substance use, addiction, and related health outcomes including HIV/AIDS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $516.9k | 4/21/26 |