This $1,288,466 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) will fund a randomized trial to evaluate the effectiveness and implementation of a peer-delivered behavioral activation and problem-solving intervention called "Peer Activate-LAI" for improving adherence to long-acting injectable pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) among a predominantly Black, substance-using population living with or at high risk for HIV in Baltimore, MD. The study will assess the intervention's impact on LAI PrEP/ART adherence, substance use, and the moderating effects of structural racism and discrimination over 12 months. The project will also examine the feasibility, acceptability, fidelity, and adoption of Peer Activate-LAI, as well as its economic viability and cost-effectiveness. The University of Maryland, Baltimore is the prime grantee for this award, which began on August 1, 2024 and will run through May 31, 2029.
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