This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) provides $622,957.00 to Duke University to conduct research on the impact of new tobacco product designs and synthetic additives on use initiation and preference behavior.
The key objectives are to: 1) Analyze the chemical composition of nicotine pouch products and "non-menthol" cigarettes, focusing on flavors, sweeteners, and forms of nicotine; 2) Examine the behavioral effects of sweeteners and nicotine forms on initiation of oral nicotine pouch consumption in mice; and 3) Quantify the effects of synthetic cooling agents in "non-menthol" cigarettes on sensory respiratory irritation response in mice. This research aims to provide critical scientific evidence to inform the Food and Drug Administration's regulation of these novel tobacco and nicotine products.
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